Nucleolar organizer regions

a prognostic factor in infiltrating ductal carcinoma in the breast.

M. Canepa, C. Gambini, L. Borgiani, A. Pastorino, G. Buccaran, L. Gallo, A. Storace, S. Rovida

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

By means of an AgNOR technique, the authors have carried out a retrospective study on proliferative activity in 170 cases of infiltrating ductal breast carcinoma (so-called carcinoma NOS). The follow-up period was 138 months. A statistically significant correlation was found between AgNOR score and outcome of the disease ("vital status"), clinical stage and OS respectively. By means of discriminant analysis a threshold value of AgNOR score was identified (= 9.5) which distinguished two risk groups among the cases under examination. Those cases with an average AgNOR score below the threshold value showed a favourable prognosis. The cases with an AgNOR score greater than 9.5 had an unfavourable outcome. The authors suggest that AgNOR score may be used as a prognostic parameter in breast carcinoma.

Original languageEnglish
Pages (from-to)151-162
Number of pages12
JournalPathologica
Volume85
Issue number1096
Publication statusPublished - Mar 1993

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Carcinoma, Ductal, Breast
Nucleolus Organizer Region
Discriminant Analysis
nucleolar organizer region associated proteins
Retrospective Studies
Breast Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Canepa, M., Gambini, C., Borgiani, L., Pastorino, A., Buccaran, G., Gallo, L., ... Rovida, S. (1993). Nucleolar organizer regions: a prognostic factor in infiltrating ductal carcinoma in the breast. Pathologica, 85(1096), 151-162.

Nucleolar organizer regions : a prognostic factor in infiltrating ductal carcinoma in the breast. / Canepa, M.; Gambini, C.; Borgiani, L.; Pastorino, A.; Buccaran, G.; Gallo, L.; Storace, A.; Rovida, S.

In: Pathologica, Vol. 85, No. 1096, 03.1993, p. 151-162.

Research output: Contribution to journalArticle

Canepa, M, Gambini, C, Borgiani, L, Pastorino, A, Buccaran, G, Gallo, L, Storace, A & Rovida, S 1993, 'Nucleolar organizer regions: a prognostic factor in infiltrating ductal carcinoma in the breast.', Pathologica, vol. 85, no. 1096, pp. 151-162.
Canepa M, Gambini C, Borgiani L, Pastorino A, Buccaran G, Gallo L et al. Nucleolar organizer regions: a prognostic factor in infiltrating ductal carcinoma in the breast. Pathologica. 1993 Mar;85(1096):151-162.
Canepa, M. ; Gambini, C. ; Borgiani, L. ; Pastorino, A. ; Buccaran, G. ; Gallo, L. ; Storace, A. ; Rovida, S. / Nucleolar organizer regions : a prognostic factor in infiltrating ductal carcinoma in the breast. In: Pathologica. 1993 ; Vol. 85, No. 1096. pp. 151-162.
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