Nucleolar organizer regions and Ki-67 immunostaining in ductal breast cancer

a comparative study.

M. Canepa, C. Gambini, A. R. Sementa, L. Borgiani, S. Rovida

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

53 cases of invasive ductal (NOS) carcinomas of the breast were studied by means of an immunostaining method with Ki-67 monoclonal antibody and an argyrophilic method for the demonstration of Nucleolar Organizer Regions (AgNORs). The percentage of cancer cells with nuclear Ki-67 immunoreactivity and the mean number of NORs for each tumour were statistically related. The data obtained showed a good correlation between Ki-67 index and NOR score (rS = 0.47 - P less than 0.001). The authors suggest that the AgNOR method--which is applicable to routinely processed material--might effectively substitute Ki-67 immunostaining as a marker of cell proliferation in ductal breast cancer.

Original languageEnglish
Pages (from-to)125-132
Number of pages8
JournalPathologica
Volume82
Issue number1078
Publication statusPublished - Mar 1990

Fingerprint

Nucleolus Organizer Region
Breast Neoplasms
Carcinoma, Ductal, Breast
Neoplasms
Monoclonal Antibodies
Cell Proliferation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nucleolar organizer regions and Ki-67 immunostaining in ductal breast cancer : a comparative study. / Canepa, M.; Gambini, C.; Sementa, A. R.; Borgiani, L.; Rovida, S.

In: Pathologica, Vol. 82, No. 1078, 03.1990, p. 125-132.

Research output: Contribution to journalArticle

Canepa, M, Gambini, C, Sementa, AR, Borgiani, L & Rovida, S 1990, 'Nucleolar organizer regions and Ki-67 immunostaining in ductal breast cancer: a comparative study.', Pathologica, vol. 82, no. 1078, pp. 125-132.
Canepa, M. ; Gambini, C. ; Sementa, A. R. ; Borgiani, L. ; Rovida, S. / Nucleolar organizer regions and Ki-67 immunostaining in ductal breast cancer : a comparative study. In: Pathologica. 1990 ; Vol. 82, No. 1078. pp. 125-132.
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