By means of a silver staining method, nucleolar Organizer region-associated proteins have been evaluated on paraffin sections of 34 cases of malignant mesothelioma and 16 cases of benign mesothelial hyperplasia, the diagnoses of which had been supported by light and electron microscopic observation. Argyrophilic nucleolar organizer regions (AgNORs) were counted by three independent observers and a mean score was determined for each case. A significant difference was found between the numbers of AgNORs in malignant mesothelioma and those in benign mesothelial hyperplasia. We conclude that AgNOR counts may be a useful method in the diagnosis of mesothelial proliferations, especially on small pleuroscopic biopsies, when it can, at times, be very difficult to establish whether the mesothelial proliferation is malignant or benign, on purely morphological grounds.
|Number of pages||3|
|Journal||European Respiratory Review|
|Publication status||Published - 1993|
- nucleolar organizer regions
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine