Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.

L. Anselmi; A. R. Sementa; L. Borgiani; A. Banderali; S. Rovida

Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.

L. Anselmi, A. R. Sementa, L. Borgiani, A. Banderali, S. Rovida

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.

Original language	English
Pages (from-to)	653-662
Number of pages	10
Journal	Pathologica
Volume	82
Issue number	1082
Publication status	Published - Nov 1990

ASJC Scopus subject areas

Pathology and Forensic Medicine

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title = "Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.",

abstract = "By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.",

author = "L. Anselmi and Sementa, {A. R.} and L. Borgiani and A. Banderali and S. Rovida",

year = "1990",

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volume = "82",

pages = "653--662",

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T2 - a quantitative analysis.

AU - Anselmi, L.

AU - Sementa, A. R.

AU - Borgiani, L.

AU - Banderali, A.

AU - Rovida, S.

PY - 1990/11

Y1 - 1990/11

N2 - By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.

AB - By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.

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