Nucleolar organizer regions (NORs) in normal and pathological liver: a quantitative analysis.

L. Anselmi, A. R. Sementa, L. Borgiani, A. Banderali, S. Rovida

Research output: Contribution to journalArticlepeer-review

Abstract

By means of a silver staining method, Nucleolar Organizer Region-associated proteins (NORs) have been evaluated on paraffin sections of a series of 58 ultrasound-guided liver biopsy specimens. These included 12 normal livers, 12 cirrhotic livers, 12 cases of chronic hepatitis and 22 cases of hepatocellular carcinoma. A significant difference (P less than 0.001) was found between the mean AgNOR scores of the normal and pathological biopsies, and between the non-neoplastic and the carcinomatous lesions. The authors suggest that AgNOR counts, in combination with conventional histocytological criteria, may be a useful method in the diagnosis of liver diseases.

Original languageEnglish
Pages (from-to)653-662
Number of pages10
JournalPathologica
Volume82
Issue number1082
Publication statusPublished - Nov 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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