Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression

Maurizio Miglino; Nicoletta Colombo; Raffaella Grasso; Carlo Marani; Marino Clavio; Gian Matteo Pica; Filippo Ballerini; Chiara Ghiggi; Paola Minetto; Fabio Guolo; Angelo Michele Carella; Marco Gobbi

doi:10.3109/10428194.2012.681658

Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression

Maurizio Miglino, Nicoletta Colombo, Raffaella Grasso, Carlo Marani, Marino Clavio, Gian Matteo Pica, Filippo Ballerini, Chiara Ghiggi, Paola Minetto, Fabio Guolo, Angelo Michele Carella, Marco Gobbi

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the clinical value of minimal residual disease (MRD) monitoring by cytofluorimetric methods, Wilms tumor gene 1 (WT1) expression and the study of nucleophosmin gene (NPM) mutations in a series of 26 patients with NPM-mutated de novo acute myeloid leukemia (NPM-AML) who achieved complete hematological remission after conventional chemotherapy. The relapse risk was significantly lower only in patients achieving a NPM molecular complete response (NPM mol-CR) and confirmed NPM mol-CR (non-detectable NPM mutations in two consecutive marrow samples). The disease-free survival (DFS) of patients achieving a

Original language	English
Pages (from-to)	2214-2217
Number of pages	4
Journal	Leukemia and Lymphoma
Volume	53
Issue number	11
DOIs	https://doi.org/10.3109/10428194.2012.681658
Publication status	Published - Nov 2012

Keywords

AML
MRD
NPM
WT1

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Miglino, M., Colombo, N., Grasso, R., Marani, C., Clavio, M., Pica, G. M., Ballerini, F., Ghiggi, C., Minetto, P., Guolo, F., Carella, A. M., & Gobbi, M. (2012). Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression. Leukemia and Lymphoma, 53(11), 2214-2217. https://doi.org/10.3109/10428194.2012.681658

Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations : Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression. / Miglino, Maurizio; Colombo, Nicoletta; Grasso, Raffaella; Marani, Carlo; Clavio, Marino; Pica, Gian Matteo; Ballerini, Filippo; Ghiggi, Chiara; Minetto, Paola; Guolo, Fabio; Carella, Angelo Michele; Gobbi, Marco.

In: Leukemia and Lymphoma, Vol. 53, No. 11, 11.2012, p. 2214-2217.

Research output: Contribution to journal › Article › peer-review

Miglino, M, Colombo, N, Grasso, R, Marani, C, Clavio, M, Pica, GM, Ballerini, F, Ghiggi, C, Minetto, P, Guolo, F, Carella, AM & Gobbi, M 2012, 'Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression', Leukemia and Lymphoma, vol. 53, no. 11, pp. 2214-2217. https://doi.org/10.3109/10428194.2012.681658

Miglino M, Colombo N, Grasso R, Marani C, Clavio M, Pica GM et al. Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression. Leukemia and Lymphoma. 2012 Nov;53(11):2214-2217. https://doi.org/10.3109/10428194.2012.681658

Miglino, Maurizio ; Colombo, Nicoletta ; Grasso, Raffaella ; Marani, Carlo ; Clavio, Marino ; Pica, Gian Matteo ; Ballerini, Filippo ; Ghiggi, Chiara ; Minetto, Paola ; Guolo, Fabio ; Carella, Angelo Michele ; Gobbi, Marco. / Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations : Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression. In: Leukemia and Lymphoma. 2012 ; Vol. 53, No. 11. pp. 2214-2217.

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abstract = "We compared the clinical value of minimal residual disease (MRD) monitoring by cytofluorimetric methods, Wilms tumor gene 1 (WT1) expression and the study of nucleophosmin gene (NPM) mutations in a series of 26 patients with NPM-mutated de novo acute myeloid leukemia (NPM-AML) who achieved complete hematological remission after conventional chemotherapy. The relapse risk was significantly lower only in patients achieving a NPM molecular complete response (NPM mol-CR) and confirmed NPM mol-CR (non-detectable NPM mutations in two consecutive marrow samples). The disease-free survival (DFS) of patients achieving a ",

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AU - Marani, Carlo

AU - Clavio, Marino

AU - Pica, Gian Matteo

AU - Ballerini, Filippo

AU - Ghiggi, Chiara

AU - Minetto, Paola

AU - Guolo, Fabio

AU - Carella, Angelo Michele

AU - Gobbi, Marco

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Nucleophosmin gene-based monitoring in de novo cytogenetically normal acute myeloid leukemia with nucleophosmin gene mutations: Comparison with cytofluorimetric analysis and study of Wilms tumor gene 1 expression

Abstract

Keywords

ASJC Scopus subject areas

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