TY - JOUR
T1 - Nucleoside transport in activated macrophages
AU - Busolo, Franco
AU - Conventi, Luciano
AU - Gatti, Carlo
AU - Monti, Daniela
AU - Troiano, Leonarda
AU - Franceschi, Claudio
PY - 1989/4/14
Y1 - 1989/4/14
N2 - The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-γ, a stimulus able to activate macrophage and to induce the production of tumor necrosis factor-α, within few hours markedly increased [3H]-uridine uptake by mouse macrophage. Other stimuli devoid of activation capacity, such as inert phagocytable latex beads, did not affect this phenomenon, which appeared to be related to macrophage activation. The increase in [3H]-uridine uptake may be an useful phenomenon in studing the early biochemical events associated with macrophage activation.
AB - The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-γ, a stimulus able to activate macrophage and to induce the production of tumor necrosis factor-α, within few hours markedly increased [3H]-uridine uptake by mouse macrophage. Other stimuli devoid of activation capacity, such as inert phagocytable latex beads, did not affect this phenomenon, which appeared to be related to macrophage activation. The increase in [3H]-uridine uptake may be an useful phenomenon in studing the early biochemical events associated with macrophage activation.
UR - http://www.scopus.com/inward/record.url?scp=0024507932&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024507932&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(89)91663-X
DO - 10.1016/0006-291X(89)91663-X
M3 - Article
C2 - 2496690
AN - SCOPUS:0024507932
VL - 160
SP - 354
EP - 361
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -