Nucleoside transport in activated macrophages

Franco Busolo, Luciano Conventi, Carlo Gatti, Daniela Monti, Leonarda Troiano, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-γ, a stimulus able to activate macrophage and to induce the production of tumor necrosis factor-α, within few hours markedly increased [3H]-uridine uptake by mouse macrophage. Other stimuli devoid of activation capacity, such as inert phagocytable latex beads, did not affect this phenomenon, which appeared to be related to macrophage activation. The increase in [3H]-uridine uptake may be an useful phenomenon in studing the early biochemical events associated with macrophage activation.

Original languageEnglish
Pages (from-to)354-361
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume160
Issue number1
DOIs
Publication statusPublished - Apr 14 1989

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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