Nucleosomal repeat length in active and inactive genes

Alessandro De Ambrosis, Nicoletta Ferrari, Stefano Bonassi, Giorgio Vidali

Research output: Contribution to journalArticlepeer-review

Abstract

Nucleosomal repeat lengths of total chromatin, H4 histone and β-DR genes have been measured in logarithmically growing HeLa cells. We have detected significant differences in nucleosomal spacing between inactive chromatin and chromatin regions actively engaged in transcription. These differences are also maintained in metaphase chromosomes at times when transcription ceases although a shortening in nucleosomal repeat length is observed in active and inactive chromatin. These observations support a model where DNA-core histone interactions are temporarily altered to allow selective remodelling of chromatin organization.

Original languageEnglish
Pages (from-to)120-122
Number of pages3
JournalFEBS Letters
Volume225
Issue number1-2
DOIs
Publication statusPublished - Dec 10 1987

Keywords

  • Chromatin structure
  • Nucleosomal spacing
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology
  • Genetics
  • Structural Biology

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