Nucleus basalis of Meynert damage and cognition in patients with multiple sclerosis

Franziska E. Hildesheim, Ralph H.B. Benedict, Robert Zivadinov, Michael G. Dwyer, Tom Fuchs, Dejan Jakimovski, Bianca Weinstock-Guttman, Niels Bergsland

Research output: Contribution to journalArticlepeer-review


Background: The nucleus basalis of Meynert (NBM), representing the major source of cerebral cholinergic innervations, is vulnerable to neurodegeneration in Alzheimer’s and Parkinson’s disease. Objective: To determine associations between NBM properties and cognitive outcomes in patients with multiple sclerosis (PwMS). Methods: 84 PwMS and 19 controls underwent 3T MRI, the Paced Auditory Serial Addition Test (PASAT) and subtests of the Brief International Cognitive Assessment for MS (BICAMS). NBM volume, fractional anisotropy, mean diffusivity (MD), axial diffusivity and radial diffusivity (D) were calculated. Analyses assessed relationships between cognition and NBM measures. Linear regressions evaluated the prognostic value of baseline measures in predicting cognitive change over 3 years of follow-up (n = 67). Results: Cognitive tests correlated with NBM diffusivity in PwMS (range r = – 0.29 to r = – 0.40, p < 0.05). After accounting for NBM volume, NBM MD and D explained additional variance (adjusted R2 range 0.08–0.20, p < 0.05). Correlations between NBM imaging metrics and cognitive tests remained significant when including imaging parameters of other cognitive key brain regions in the models. After controlling for age, education, and baseline cognitive test score, NBM measures predicted change in cognition over follow-up in 5 of 10 and 2 of 10 assessments in the relapsing–remitting sample (n = 43) (adjusted R2 range from 0.23 to 0.38, p < 0.05) and secondary progressive sample (adjusted R2 of 0.280 and 0.183), respectively. Conclusions: NBM damage is linked to cognitive impairment in PwMS.

Original languageEnglish
JournalJournal of Neurology
Publication statusAccepted/In press - 2021


  • Atrophy
  • Cognition
  • Diffusion tensor imaging
  • Multiple sclerosis
  • Nucleus basalis of Meynert

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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