Numerical chromosomal aberrations in thyroid tumors detected by double fluorescence in situ hybridization

D. Taruscio, M. L. Carcangiu, T. Ried, D. C. Ward

Research output: Contribution to journalArticle

Abstract

Double fluorescence in situ hybridization with DNA probes specific for the (peri)centromeric regions of chromosomes 3, 7, 9, 11, 12, 18, and X was performed on fresh isolated nuclei and frozen tissue sections prepared from 2 nodular hyperplasias, 2 adenomas, and 7 papillary carcinomas of the thyroid in order to detect numerical chromosomal changes. Numerical chromosomal aberrations were found in all malignant specimens examined. A consistent presence of at least two trisomies was detected in most cases, especially in the follicular variant specimens; the highest degree of trisomy was observed for chromosome 12. Isolated monosomies of moderate degree for different chromosomes were found in 1 adenoma and 2 papillary carcinomas. Severe monosomy of chromosome 9 was the only significant feature observed in the single metastatic papillary carcinoma.

Original languageEnglish
Pages (from-to)180-185
Number of pages6
JournalGenes Chromosomes and Cancer
Volume9
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

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