Numerous SP-positive pyramidal neurons in cat neocortex are glutamate-positive

Fiorenzo Conti, Mara Fabri, Andrea Minelli

Research output: Contribution to journalArticlepeer-review


An immunocytochemical technique that allows visualization of two antigens in the same neurons was used to verify the possibility that some neocortical pyramidal neurons contain both glutamate (Glu) and substance P (SP) immunoreactivity. The results show that a large fraction of SP-positive pyramidal neurons are also Glu-positive, and indicate that in a small population of cortical neurons a fast excitatory synaptic transmitter and a slow peptidic modulator coexist.

Original languageEnglish
Pages (from-to)140-143
Number of pages4
JournalBrain Research
Issue number1
Publication statusPublished - Dec 18 1992


  • Cerebral cortex
  • Glutamate
  • Pyramidal neuron
  • Substance P

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)


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