Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

Andrea Poli, Carlo M Barbagallo, Arrigo F G Cicero, Alberto Corsini, Enzo Manzato, Bruno Trimarco, Franco Bernini, Francesco Visioli, Alfio Bianchi, Giuseppe Canzone, Claudio Crescini, Saula de Kreutzenberg, Nicola Ferrara, Marco Gambacciani, Andrea Ghiselli, Carla Lubrano, Giuseppe Marelli, Walter Marrocco, Vincenzo Montemurro, Damiano ParrettiRoberto Pedretti, Francesco Perticone, Roberto Stella, Franca Marangoni

Research output: Contribution to journalReview article

Abstract

Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalPharmacological Research
Volume134
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Functional Food
Dietary Supplements
Cholesterol
Berberine
Phytosterols
Lovastatin
beta-Glucans
LDL Cholesterol
Life Style
Cardiovascular Diseases
Physicians
Health
Pharmaceutical Preparations

Cite this

Poli, A., Barbagallo, C. M., Cicero, A. F. G., Corsini, A., Manzato, E., Trimarco, B., ... Marangoni, F. (2018). Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper. Pharmacological Research, 134, 51-60. https://doi.org/10.1016/j.phrs.2018.05.015

Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper. / Poli, Andrea; Barbagallo, Carlo M; Cicero, Arrigo F G; Corsini, Alberto; Manzato, Enzo; Trimarco, Bruno; Bernini, Franco; Visioli, Francesco; Bianchi, Alfio; Canzone, Giuseppe; Crescini, Claudio; de Kreutzenberg, Saula; Ferrara, Nicola; Gambacciani, Marco; Ghiselli, Andrea; Lubrano, Carla; Marelli, Giuseppe; Marrocco, Walter; Montemurro, Vincenzo; Parretti, Damiano; Pedretti, Roberto; Perticone, Francesco; Stella, Roberto; Marangoni, Franca.

In: Pharmacological Research, Vol. 134, 08.2018, p. 51-60.

Research output: Contribution to journalReview article

Poli, A, Barbagallo, CM, Cicero, AFG, Corsini, A, Manzato, E, Trimarco, B, Bernini, F, Visioli, F, Bianchi, A, Canzone, G, Crescini, C, de Kreutzenberg, S, Ferrara, N, Gambacciani, M, Ghiselli, A, Lubrano, C, Marelli, G, Marrocco, W, Montemurro, V, Parretti, D, Pedretti, R, Perticone, F, Stella, R & Marangoni, F 2018, 'Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper', Pharmacological Research, vol. 134, pp. 51-60. https://doi.org/10.1016/j.phrs.2018.05.015
Poli, Andrea ; Barbagallo, Carlo M ; Cicero, Arrigo F G ; Corsini, Alberto ; Manzato, Enzo ; Trimarco, Bruno ; Bernini, Franco ; Visioli, Francesco ; Bianchi, Alfio ; Canzone, Giuseppe ; Crescini, Claudio ; de Kreutzenberg, Saula ; Ferrara, Nicola ; Gambacciani, Marco ; Ghiselli, Andrea ; Lubrano, Carla ; Marelli, Giuseppe ; Marrocco, Walter ; Montemurro, Vincenzo ; Parretti, Damiano ; Pedretti, Roberto ; Perticone, Francesco ; Stella, Roberto ; Marangoni, Franca. / Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper. In: Pharmacological Research. 2018 ; Vol. 134. pp. 51-60.
@article{f0eee562b148426686c64c7ef3293004,
title = "Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper",
abstract = "Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25{\%}, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ({"}concordance{"}).",
author = "Andrea Poli and Barbagallo, {Carlo M} and Cicero, {Arrigo F G} and Alberto Corsini and Enzo Manzato and Bruno Trimarco and Franco Bernini and Francesco Visioli and Alfio Bianchi and Giuseppe Canzone and Claudio Crescini and {de Kreutzenberg}, Saula and Nicola Ferrara and Marco Gambacciani and Andrea Ghiselli and Carla Lubrano and Giuseppe Marelli and Walter Marrocco and Vincenzo Montemurro and Damiano Parretti and Roberto Pedretti and Francesco Perticone and Roberto Stella and Franca Marangoni",
note = "Copyright {\circledC} 2018 Elsevier Ltd. All rights reserved.",
year = "2018",
month = "8",
doi = "10.1016/j.phrs.2018.05.015",
language = "English",
volume = "134",
pages = "51--60",
journal = "Pharmacological Research",
issn = "1043-6618",
publisher = "Academic Press",

}

TY - JOUR

T1 - Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper

AU - Poli, Andrea

AU - Barbagallo, Carlo M

AU - Cicero, Arrigo F G

AU - Corsini, Alberto

AU - Manzato, Enzo

AU - Trimarco, Bruno

AU - Bernini, Franco

AU - Visioli, Francesco

AU - Bianchi, Alfio

AU - Canzone, Giuseppe

AU - Crescini, Claudio

AU - de Kreutzenberg, Saula

AU - Ferrara, Nicola

AU - Gambacciani, Marco

AU - Ghiselli, Andrea

AU - Lubrano, Carla

AU - Marelli, Giuseppe

AU - Marrocco, Walter

AU - Montemurro, Vincenzo

AU - Parretti, Damiano

AU - Pedretti, Roberto

AU - Perticone, Francesco

AU - Stella, Roberto

AU - Marangoni, Franca

N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.

PY - 2018/8

Y1 - 2018/8

N2 - Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").

AB - Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").

U2 - 10.1016/j.phrs.2018.05.015

DO - 10.1016/j.phrs.2018.05.015

M3 - Review article

C2 - 29859248

VL - 134

SP - 51

EP - 60

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

ER -