Abstract
Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").
| Original language | English |
|---|---|
| Pages (from-to) | 51-60 |
| Number of pages | 10 |
| Journal | Pharmacological Research |
| Volume | 134 |
| DOIs | |
| Publication status | Published - Aug 2018 |
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Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper. / Poli, Andrea; Barbagallo, Carlo M; Cicero, Arrigo F G; Corsini, Alberto; Manzato, Enzo; Trimarco, Bruno; Bernini, Franco; Visioli, Francesco; Bianchi, Alfio; Canzone, Giuseppe; Crescini, Claudio; de Kreutzenberg, Saula; Ferrara, Nicola; Gambacciani, Marco; Ghiselli, Andrea; Lubrano, Carla; Marelli, Giuseppe; Marrocco, Walter; Montemurro, Vincenzo; Parretti, Damiano; Pedretti, Roberto; Perticone, Francesco; Stella, Roberto; Marangoni, Franca.
In: Pharmacological Research, Vol. 134, 08.2018, p. 51-60.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Nutraceuticals and functional foods for the control of plasma cholesterol levels. An intersociety position paper
AU - Poli, Andrea
AU - Barbagallo, Carlo M
AU - Cicero, Arrigo F G
AU - Corsini, Alberto
AU - Manzato, Enzo
AU - Trimarco, Bruno
AU - Bernini, Franco
AU - Visioli, Francesco
AU - Bianchi, Alfio
AU - Canzone, Giuseppe
AU - Crescini, Claudio
AU - de Kreutzenberg, Saula
AU - Ferrara, Nicola
AU - Gambacciani, Marco
AU - Ghiselli, Andrea
AU - Lubrano, Carla
AU - Marelli, Giuseppe
AU - Marrocco, Walter
AU - Montemurro, Vincenzo
AU - Parretti, Damiano
AU - Pedretti, Roberto
AU - Perticone, Francesco
AU - Stella, Roberto
AU - Marangoni, Franca
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").
AB - Current evidence shows that cholesterol management either reduces the likelihood of cardiovascular disease (CVD) or slows down its progression. Hence, it is important that all health professionals make appropriate use of all the available intervention strategies to control risk factors: from dietary improvement and positive lifestyle changes to the use of functional foods, food supplements, and drugs. This review examines the effect of the most frequently occurring cholesterol-lowering substances in functional foods or in supplements across Europe, namely plant sterols and stanols, monacolin K found in red yeast rice, berberine and beta-glucans. We conclude that currently available supplements and functional foods can effectively reduce plasma LDL cholesterol levels by about 5 to 25%, either alone or in combination. Suitable candidates for these products are mainly individuals at low absolute cardiovascular risk at a young age or according to classic algorithms. Of note, despite being freely available for purchase, these products should be used following shared agreement between the physician and the patient ("concordance").
U2 - 10.1016/j.phrs.2018.05.015
DO - 10.1016/j.phrs.2018.05.015
M3 - Review article
C2 - 29859248
VL - 134
SP - 51
EP - 60
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
ER -