TY - JOUR
T1 - Nutrient-based dietary patterns and nasopharyngeal cancer
T2 - Evidence from an exploratory factor analysis
AU - Edefonti, V.
AU - Nicolussi, F.
AU - Polesel, J.
AU - Bravi, F.
AU - Bosetti, C.
AU - Garavello, W.
AU - La Vecchia, C.
AU - Bidoli, E.
AU - Decarli, A.
AU - Serraino, D.
AU - Calza, S.
AU - Ferraroni, M.
PY - 2015/2/3
Y1 - 2015/2/3
N2 - Background:To our knowledge, no study assessed the association between dietary patterns and nasopharyngeal carcinoma (NPC) in low-incidence areas.Methods:We examined this association in a hospital-based case-control study carried out in Italy between 1992 and 2008, including 198 incident NPC cases and 594 controls. A posteriori dietary patterns were identified through principal component factor analysis performed on 28 nutrients and minerals derived from a 78-item food-frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on tertiles of factor scores.Results:We identified five dietary patterns named Animal products, Starch-rich, Vitamins and fibre, Animal unsaturated fatty acids (AUFAs), and Vegetable unsaturated fatty acids (VUFAs). The Animal product (OR=2.62, 95% CI=1.67-4.13, for the highest vs lowest score tertile), Starch-rich (OR=2.05, 95% CI=1.27-3.33), and VUFA (OR=1.90, 95% CI=1.22-2.96) patterns were positively associated with NPC. The AUFA pattern showed a positive association of borderline significance, whereas the Vitamins and fibre pattern was nonsignificantly but inversely associated with NPC.Conclusions:These findings suggest that diets rich in animal products, starch, and fats are positively related to NPC risk in this low-incidence country.
AB - Background:To our knowledge, no study assessed the association between dietary patterns and nasopharyngeal carcinoma (NPC) in low-incidence areas.Methods:We examined this association in a hospital-based case-control study carried out in Italy between 1992 and 2008, including 198 incident NPC cases and 594 controls. A posteriori dietary patterns were identified through principal component factor analysis performed on 28 nutrients and minerals derived from a 78-item food-frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on tertiles of factor scores.Results:We identified five dietary patterns named Animal products, Starch-rich, Vitamins and fibre, Animal unsaturated fatty acids (AUFAs), and Vegetable unsaturated fatty acids (VUFAs). The Animal product (OR=2.62, 95% CI=1.67-4.13, for the highest vs lowest score tertile), Starch-rich (OR=2.05, 95% CI=1.27-3.33), and VUFA (OR=1.90, 95% CI=1.22-2.96) patterns were positively associated with NPC. The AUFA pattern showed a positive association of borderline significance, whereas the Vitamins and fibre pattern was nonsignificantly but inversely associated with NPC.Conclusions:These findings suggest that diets rich in animal products, starch, and fats are positively related to NPC risk in this low-incidence country.
KW - diet; dietary patterns; factor analysis; nutrients; nasopharyngeal cancer
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U2 - 10.1038/bjc.2014.611
DO - 10.1038/bjc.2014.611
M3 - Article
C2 - 25490523
AN - SCOPUS:84922269670
VL - 112
SP - 446
EP - 454
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 3
ER -