TY - JOUR
T1 - Nutrient-based dietary patterns and pancreatic cancer risk
AU - Bosetti, Cristina
AU - Bravi, Francesca
AU - Turati, Federica
AU - Edefonti, Valeria
AU - Polesel, Jerry
AU - Decarli, Adriano
AU - Negri, Eva
AU - Talamini, Renato
AU - Franceschi, Silvia
AU - La Vecchia, Carlo
AU - Zeegers, Maurice P.
PY - 2013/3
Y1 - 2013/3
N2 - Purpose: Few data are available on the role of combinations of foods and/or nutrients on pancreatic cancer risk. To add further information on dietary patterns potentially associated to pancreatic cancer, we applied an exploratory principal component factor analysis on 28 major nutrients derived from an Italian case-control study. Methods: Cases were 326 incident pancreatic cancer cases and controls 652 frequency-matched controls admitted to hospital for non-neoplastic diseases. Dietary information was collected through a validated and reproducible food frequency questionnaire. Multiple logistic regression models adjusted for sociodemographic variables and major recognized risk factors for pancreatic cancer were used to estimate the odds ratios (OR) of pancreatic cancer for each dietary pattern. Results: We identified four dietary patterns-named " animal products," " unsaturated fats," " vitamins and fiber," and " starch rich," that explain 75% of the total variance in nutrient intake in this population. After allowing for all the four patterns, positive associations were found for the animal products and the starch rich patterns, the OR for the highest versus the lowest quartiles being 2.03 (95% confidence interval [CI], 1.29-3.19) and 1.69 (95% CI, 1.02-2.79), respectively; an inverse association emerged for the vitamins and fiber pattern (OR, 0.55; 95% CI, 0.35-0.86), whereas no association was observed for the unsaturated fats pattern (OR, 1.13; 95% CI, 0.71-1.78). Conclusions: A diet characterized by a high consumption of meat and other animal products, as well as of (refined) cereals and sugars, is positively associated with pancreatic cancer risk, whereas a diet rich in fruit and vegetables is inversely associated.
AB - Purpose: Few data are available on the role of combinations of foods and/or nutrients on pancreatic cancer risk. To add further information on dietary patterns potentially associated to pancreatic cancer, we applied an exploratory principal component factor analysis on 28 major nutrients derived from an Italian case-control study. Methods: Cases were 326 incident pancreatic cancer cases and controls 652 frequency-matched controls admitted to hospital for non-neoplastic diseases. Dietary information was collected through a validated and reproducible food frequency questionnaire. Multiple logistic regression models adjusted for sociodemographic variables and major recognized risk factors for pancreatic cancer were used to estimate the odds ratios (OR) of pancreatic cancer for each dietary pattern. Results: We identified four dietary patterns-named " animal products," " unsaturated fats," " vitamins and fiber," and " starch rich," that explain 75% of the total variance in nutrient intake in this population. After allowing for all the four patterns, positive associations were found for the animal products and the starch rich patterns, the OR for the highest versus the lowest quartiles being 2.03 (95% confidence interval [CI], 1.29-3.19) and 1.69 (95% CI, 1.02-2.79), respectively; an inverse association emerged for the vitamins and fiber pattern (OR, 0.55; 95% CI, 0.35-0.86), whereas no association was observed for the unsaturated fats pattern (OR, 1.13; 95% CI, 0.71-1.78). Conclusions: A diet characterized by a high consumption of meat and other animal products, as well as of (refined) cereals and sugars, is positively associated with pancreatic cancer risk, whereas a diet rich in fruit and vegetables is inversely associated.
KW - Case-control study
KW - Diet
KW - Dietary patterns
KW - Pancreatic cancer
KW - Risk factors
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U2 - 10.1016/j.annepidem.2012.12.005
DO - 10.1016/j.annepidem.2012.12.005
M3 - Article
C2 - 23332711
AN - SCOPUS:84873433933
VL - 23
SP - 124
EP - 128
JO - Annals of Epidemiology
JF - Annals of Epidemiology
SN - 1047-2797
IS - 3
ER -