Nutrient-based dietary patterns and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

V. Edefonti, M. Hashibe, F. Ambrogi, M. Parpinel, F. Bravi, R. Talamini, F. Levi, G. Yu, H. Morgenstern, K. Kelsey, M. Mcclean, S. Schantz, Z. Zhang, S. Chuang, P. Boffetta, C. La vecchia, A. Decarli

Research output: Contribution to journalArticle

Abstract

Background: The association between dietary patterns and head and neck cancer has rarely been addressed. Patients and methods: We used individual-level pooled data from five case-control studies (2452 cases and 5013 controls) participating in the International Head and Neck Cancer Epidemiology consortium. A posteriori dietary patterns were identified through a principal component factor analysis carried out on 24 nutrients derived from study-specific food-frequency questionnaires. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional logistic regression models on quintiles of factor scores. Results: We identified three major dietary patterns named 'animal products and cereals', 'antioxidant vitamins and fiber', and 'fats'. The 'antioxidant vitamins and fiber' pattern was inversely related to oral and pharyngeal cancer (OR = 0.57, 95% CI 0.43-0.76 for the highest versus the lowest score quintile). The 'animal products and cereals' pattern was positively associated with laryngeal cancer (OR = 1.54, 95% CI 1.12-2.11), whereas the 'fats' pattern was inversely associated with oral and pharyngeal cancer (OR = 0.78, 95% CI 0.63-0.97) and positively associated with laryngeal cancer (OR = 1.69, 95% CI 1.22-2.34). Conclusions: These findings suggest that diets rich in animal products, cereals, and fats are positively related to laryngeal cancer, and those rich in fruit and vegetables inversely related to oral and pharyngeal cancer.

Original languageEnglish
Article numbermdr548
Pages (from-to)1869-1880
Number of pages12
JournalAnnals of Oncology
Volume23
Issue number7
DOIs
Publication statusPublished - Jul 2012

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Head and Neck Neoplasms
Pharyngeal Neoplasms
Epidemiology
Odds Ratio
Laryngeal Neoplasms
Confidence Intervals
Mouth Neoplasms
Food
Fats
Vitamins
Antioxidants
Logistic Models
Principal Component Analysis
Vegetables
Statistical Factor Analysis
Case-Control Studies
Fruit
Diet
Edible Grain

Keywords

  • Diet
  • Dietary patterns
  • Factor analysis
  • Head and neck cancer
  • INHANCE
  • Nutrients

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Nutrient-based dietary patterns and the risk of head and neck cancer : A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. / Edefonti, V.; Hashibe, M.; Ambrogi, F.; Parpinel, M.; Bravi, F.; Talamini, R.; Levi, F.; Yu, G.; Morgenstern, H.; Kelsey, K.; Mcclean, M.; Schantz, S.; Zhang, Z.; Chuang, S.; Boffetta, P.; La vecchia, C.; Decarli, A.

In: Annals of Oncology, Vol. 23, No. 7, mdr548, 07.2012, p. 1869-1880.

Research output: Contribution to journalArticle

Edefonti, V, Hashibe, M, Ambrogi, F, Parpinel, M, Bravi, F, Talamini, R, Levi, F, Yu, G, Morgenstern, H, Kelsey, K, Mcclean, M, Schantz, S, Zhang, Z, Chuang, S, Boffetta, P, La vecchia, C & Decarli, A 2012, 'Nutrient-based dietary patterns and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium', Annals of Oncology, vol. 23, no. 7, mdr548, pp. 1869-1880. https://doi.org/10.1093/annonc/mdr548
Edefonti, V. ; Hashibe, M. ; Ambrogi, F. ; Parpinel, M. ; Bravi, F. ; Talamini, R. ; Levi, F. ; Yu, G. ; Morgenstern, H. ; Kelsey, K. ; Mcclean, M. ; Schantz, S. ; Zhang, Z. ; Chuang, S. ; Boffetta, P. ; La vecchia, C. ; Decarli, A. / Nutrient-based dietary patterns and the risk of head and neck cancer : A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. In: Annals of Oncology. 2012 ; Vol. 23, No. 7. pp. 1869-1880.
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abstract = "Background: The association between dietary patterns and head and neck cancer has rarely been addressed. Patients and methods: We used individual-level pooled data from five case-control studies (2452 cases and 5013 controls) participating in the International Head and Neck Cancer Epidemiology consortium. A posteriori dietary patterns were identified through a principal component factor analysis carried out on 24 nutrients derived from study-specific food-frequency questionnaires. Odds ratios (ORs) and corresponding 95{\%} confidence intervals (CIs) were estimated using unconditional logistic regression models on quintiles of factor scores. Results: We identified three major dietary patterns named 'animal products and cereals', 'antioxidant vitamins and fiber', and 'fats'. The 'antioxidant vitamins and fiber' pattern was inversely related to oral and pharyngeal cancer (OR = 0.57, 95{\%} CI 0.43-0.76 for the highest versus the lowest score quintile). The 'animal products and cereals' pattern was positively associated with laryngeal cancer (OR = 1.54, 95{\%} CI 1.12-2.11), whereas the 'fats' pattern was inversely associated with oral and pharyngeal cancer (OR = 0.78, 95{\%} CI 0.63-0.97) and positively associated with laryngeal cancer (OR = 1.69, 95{\%} CI 1.22-2.34). Conclusions: These findings suggest that diets rich in animal products, cereals, and fats are positively related to laryngeal cancer, and those rich in fruit and vegetables inversely related to oral and pharyngeal cancer.",
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T2 - A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

AU - Edefonti, V.

AU - Hashibe, M.

AU - Ambrogi, F.

AU - Parpinel, M.

AU - Bravi, F.

AU - Talamini, R.

AU - Levi, F.

AU - Yu, G.

AU - Morgenstern, H.

AU - Kelsey, K.

AU - Mcclean, M.

AU - Schantz, S.

AU - Zhang, Z.

AU - Chuang, S.

AU - Boffetta, P.

AU - La vecchia, C.

AU - Decarli, A.

PY - 2012/7

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N2 - Background: The association between dietary patterns and head and neck cancer has rarely been addressed. Patients and methods: We used individual-level pooled data from five case-control studies (2452 cases and 5013 controls) participating in the International Head and Neck Cancer Epidemiology consortium. A posteriori dietary patterns were identified through a principal component factor analysis carried out on 24 nutrients derived from study-specific food-frequency questionnaires. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional logistic regression models on quintiles of factor scores. Results: We identified three major dietary patterns named 'animal products and cereals', 'antioxidant vitamins and fiber', and 'fats'. The 'antioxidant vitamins and fiber' pattern was inversely related to oral and pharyngeal cancer (OR = 0.57, 95% CI 0.43-0.76 for the highest versus the lowest score quintile). The 'animal products and cereals' pattern was positively associated with laryngeal cancer (OR = 1.54, 95% CI 1.12-2.11), whereas the 'fats' pattern was inversely associated with oral and pharyngeal cancer (OR = 0.78, 95% CI 0.63-0.97) and positively associated with laryngeal cancer (OR = 1.69, 95% CI 1.22-2.34). Conclusions: These findings suggest that diets rich in animal products, cereals, and fats are positively related to laryngeal cancer, and those rich in fruit and vegetables inversely related to oral and pharyngeal cancer.

AB - Background: The association between dietary patterns and head and neck cancer has rarely been addressed. Patients and methods: We used individual-level pooled data from five case-control studies (2452 cases and 5013 controls) participating in the International Head and Neck Cancer Epidemiology consortium. A posteriori dietary patterns were identified through a principal component factor analysis carried out on 24 nutrients derived from study-specific food-frequency questionnaires. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional logistic regression models on quintiles of factor scores. Results: We identified three major dietary patterns named 'animal products and cereals', 'antioxidant vitamins and fiber', and 'fats'. The 'antioxidant vitamins and fiber' pattern was inversely related to oral and pharyngeal cancer (OR = 0.57, 95% CI 0.43-0.76 for the highest versus the lowest score quintile). The 'animal products and cereals' pattern was positively associated with laryngeal cancer (OR = 1.54, 95% CI 1.12-2.11), whereas the 'fats' pattern was inversely associated with oral and pharyngeal cancer (OR = 0.78, 95% CI 0.63-0.97) and positively associated with laryngeal cancer (OR = 1.69, 95% CI 1.22-2.34). Conclusions: These findings suggest that diets rich in animal products, cereals, and fats are positively related to laryngeal cancer, and those rich in fruit and vegetables inversely related to oral and pharyngeal cancer.

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