Abstract
Background: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. Methods: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. Results: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). Conclusions: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.
| Original language | English |
|---|---|
| Pages (from-to) | 2882-2886 |
| Number of pages | 5 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 18 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2009 |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
Cite this
Nutrient dietary patterns and gastric cancer risk in Italy. / Bertuccio, Paola; Edefonti, Valeria; Bravi, Francesca; Ferraroni, Monica; Pelucchi, Claudio; Negri, Eva; Decarli, Adriano; La Vecchia, Carlo.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 11, 11.2009, p. 2882-2886.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nutrient dietary patterns and gastric cancer risk in Italy
AU - Bertuccio, Paola
AU - Edefonti, Valeria
AU - Bravi, Francesca
AU - Ferraroni, Monica
AU - Pelucchi, Claudio
AU - Negri, Eva
AU - Decarli, Adriano
AU - La Vecchia, Carlo
PY - 2009/11
Y1 - 2009/11
N2 - Background: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. Methods: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. Results: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). Conclusions: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.
AB - Background: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. Methods: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. Results: We identified four major dietary patterns, named "animal products", "vitamins and fiber", "vegetable unsaturated fatty acids", and "starch-rich". We observed a positive association between gastric cancer risk and the "animal products" (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the "starch-rich" (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The "vitamins and fiber" pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the "vegetable unsaturated fatty acids" pattern (OR, 0.89; 95% CI, 0.56-1.42). Conclusions: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods.
UR - http://www.scopus.com/inward/record.url?scp=72749104710&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=72749104710&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-09-0782
DO - 10.1158/1055-9965.EPI-09-0782
M3 - Article
C2 - 19861520
AN - SCOPUS:72749104710
VL - 18
SP - 2882
EP - 2886
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 11
ER -