Nutrient dietary patterns and the risk of breast and ovarian cancers

Valeria Edefonti, Adriano Decarli, Carlo La Vecchia, Cristina Bosetti, Giorgia Randi, Silvia Franceschi, Luigino Dal Maso, Monica Ferraroni

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

The issue of diet and breast and ovarian cancers has been considered in terms of foods and nutrients, but rarely in terms of dietary patterns. We examined the associations between dietary patterns and breast and ovarian cancers in 2 Italian multicentric case-control studies. Cases were 2,569 breast cancers and 1,031 ovarian cancers hospitalized in 4 Italian areas between 1991 and 1999. Controls were 3,413 women from the same hospital network. Dietary habits were investigated through a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals (CI) for both cancers were estimated using unconditional multiple logistic regression models on quartiles of factor scores and continuous factor scores. We identified 4 major dietary patterns named Animal products, Vitamins and fiber, Unsaturated fats and Starch-rich. The animal products pattern and the unsaturated fats pattern were inversely associated with breast cancer (OR = 0.74, 95% CI: 0.61-0.91 and OR = 0.83, 95% CI: 0.68-1.00, respectively, for the highest consumption quartile), whereas the starch-rich pattern was directly associated with it (OR = 1.34, 95% CI: 1.10-1.65). The vitamins and fiber pattern was inversely associated with ovarian cancer (OR = 0.77, 95% CI: 0.61-0.98), whereas the starch-rich pattern was directly associated with it (OR = 1.85, 95% CI: 1.37-2.48). In conclusion, the starch-rich pattern is potentially an unfavorable indicator of risk for both breast and ovarian cancers, while the animal products and the vitamins and fiber patterns may be associated with a reduced risk of breast and ovarian cancers, respectively.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalInternational Journal of Cancer
Volume122
Issue number3
DOIs
Publication statusPublished - Feb 1 2008

Fingerprint

Ovarian Neoplasms
Odds Ratio
Confidence Intervals
Breast Neoplasms
Food
Starch
Unsaturated Fats
Vitamins
Logistic Models
Feeding Behavior
Principal Component Analysis
Statistical Factor Analysis
Case-Control Studies
Diet
Neoplasms

Keywords

  • Breast cancer
  • Dietary patterns
  • Factor analysis
  • Nutrients
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Edefonti, V., Decarli, A., La Vecchia, C., Bosetti, C., Randi, G., Franceschi, S., ... Ferraroni, M. (2008). Nutrient dietary patterns and the risk of breast and ovarian cancers. International Journal of Cancer, 122(3), 609-613. https://doi.org/10.1002/ijc.23064

Nutrient dietary patterns and the risk of breast and ovarian cancers. / Edefonti, Valeria; Decarli, Adriano; La Vecchia, Carlo; Bosetti, Cristina; Randi, Giorgia; Franceschi, Silvia; Dal Maso, Luigino; Ferraroni, Monica.

In: International Journal of Cancer, Vol. 122, No. 3, 01.02.2008, p. 609-613.

Research output: Contribution to journalArticle

Edefonti, V, Decarli, A, La Vecchia, C, Bosetti, C, Randi, G, Franceschi, S, Dal Maso, L & Ferraroni, M 2008, 'Nutrient dietary patterns and the risk of breast and ovarian cancers', International Journal of Cancer, vol. 122, no. 3, pp. 609-613. https://doi.org/10.1002/ijc.23064
Edefonti V, Decarli A, La Vecchia C, Bosetti C, Randi G, Franceschi S et al. Nutrient dietary patterns and the risk of breast and ovarian cancers. International Journal of Cancer. 2008 Feb 1;122(3):609-613. https://doi.org/10.1002/ijc.23064
Edefonti, Valeria ; Decarli, Adriano ; La Vecchia, Carlo ; Bosetti, Cristina ; Randi, Giorgia ; Franceschi, Silvia ; Dal Maso, Luigino ; Ferraroni, Monica. / Nutrient dietary patterns and the risk of breast and ovarian cancers. In: International Journal of Cancer. 2008 ; Vol. 122, No. 3. pp. 609-613.
@article{361fc49e5ece46e8a0890c45f43183ee,
title = "Nutrient dietary patterns and the risk of breast and ovarian cancers",
abstract = "The issue of diet and breast and ovarian cancers has been considered in terms of foods and nutrients, but rarely in terms of dietary patterns. We examined the associations between dietary patterns and breast and ovarian cancers in 2 Italian multicentric case-control studies. Cases were 2,569 breast cancers and 1,031 ovarian cancers hospitalized in 4 Italian areas between 1991 and 1999. Controls were 3,413 women from the same hospital network. Dietary habits were investigated through a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95{\%} confidence intervals (CI) for both cancers were estimated using unconditional multiple logistic regression models on quartiles of factor scores and continuous factor scores. We identified 4 major dietary patterns named Animal products, Vitamins and fiber, Unsaturated fats and Starch-rich. The animal products pattern and the unsaturated fats pattern were inversely associated with breast cancer (OR = 0.74, 95{\%} CI: 0.61-0.91 and OR = 0.83, 95{\%} CI: 0.68-1.00, respectively, for the highest consumption quartile), whereas the starch-rich pattern was directly associated with it (OR = 1.34, 95{\%} CI: 1.10-1.65). The vitamins and fiber pattern was inversely associated with ovarian cancer (OR = 0.77, 95{\%} CI: 0.61-0.98), whereas the starch-rich pattern was directly associated with it (OR = 1.85, 95{\%} CI: 1.37-2.48). In conclusion, the starch-rich pattern is potentially an unfavorable indicator of risk for both breast and ovarian cancers, while the animal products and the vitamins and fiber patterns may be associated with a reduced risk of breast and ovarian cancers, respectively.",
keywords = "Breast cancer, Dietary patterns, Factor analysis, Nutrients, Ovarian cancer",
author = "Valeria Edefonti and Adriano Decarli and {La Vecchia}, Carlo and Cristina Bosetti and Giorgia Randi and Silvia Franceschi and {Dal Maso}, Luigino and Monica Ferraroni",
year = "2008",
month = "2",
day = "1",
doi = "10.1002/ijc.23064",
language = "English",
volume = "122",
pages = "609--613",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Nutrient dietary patterns and the risk of breast and ovarian cancers

AU - Edefonti, Valeria

AU - Decarli, Adriano

AU - La Vecchia, Carlo

AU - Bosetti, Cristina

AU - Randi, Giorgia

AU - Franceschi, Silvia

AU - Dal Maso, Luigino

AU - Ferraroni, Monica

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The issue of diet and breast and ovarian cancers has been considered in terms of foods and nutrients, but rarely in terms of dietary patterns. We examined the associations between dietary patterns and breast and ovarian cancers in 2 Italian multicentric case-control studies. Cases were 2,569 breast cancers and 1,031 ovarian cancers hospitalized in 4 Italian areas between 1991 and 1999. Controls were 3,413 women from the same hospital network. Dietary habits were investigated through a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals (CI) for both cancers were estimated using unconditional multiple logistic regression models on quartiles of factor scores and continuous factor scores. We identified 4 major dietary patterns named Animal products, Vitamins and fiber, Unsaturated fats and Starch-rich. The animal products pattern and the unsaturated fats pattern were inversely associated with breast cancer (OR = 0.74, 95% CI: 0.61-0.91 and OR = 0.83, 95% CI: 0.68-1.00, respectively, for the highest consumption quartile), whereas the starch-rich pattern was directly associated with it (OR = 1.34, 95% CI: 1.10-1.65). The vitamins and fiber pattern was inversely associated with ovarian cancer (OR = 0.77, 95% CI: 0.61-0.98), whereas the starch-rich pattern was directly associated with it (OR = 1.85, 95% CI: 1.37-2.48). In conclusion, the starch-rich pattern is potentially an unfavorable indicator of risk for both breast and ovarian cancers, while the animal products and the vitamins and fiber patterns may be associated with a reduced risk of breast and ovarian cancers, respectively.

AB - The issue of diet and breast and ovarian cancers has been considered in terms of foods and nutrients, but rarely in terms of dietary patterns. We examined the associations between dietary patterns and breast and ovarian cancers in 2 Italian multicentric case-control studies. Cases were 2,569 breast cancers and 1,031 ovarian cancers hospitalized in 4 Italian areas between 1991 and 1999. Controls were 3,413 women from the same hospital network. Dietary habits were investigated through a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals (CI) for both cancers were estimated using unconditional multiple logistic regression models on quartiles of factor scores and continuous factor scores. We identified 4 major dietary patterns named Animal products, Vitamins and fiber, Unsaturated fats and Starch-rich. The animal products pattern and the unsaturated fats pattern were inversely associated with breast cancer (OR = 0.74, 95% CI: 0.61-0.91 and OR = 0.83, 95% CI: 0.68-1.00, respectively, for the highest consumption quartile), whereas the starch-rich pattern was directly associated with it (OR = 1.34, 95% CI: 1.10-1.65). The vitamins and fiber pattern was inversely associated with ovarian cancer (OR = 0.77, 95% CI: 0.61-0.98), whereas the starch-rich pattern was directly associated with it (OR = 1.85, 95% CI: 1.37-2.48). In conclusion, the starch-rich pattern is potentially an unfavorable indicator of risk for both breast and ovarian cancers, while the animal products and the vitamins and fiber patterns may be associated with a reduced risk of breast and ovarian cancers, respectively.

KW - Breast cancer

KW - Dietary patterns

KW - Factor analysis

KW - Nutrients

KW - Ovarian cancer

UR - http://www.scopus.com/inward/record.url?scp=37349035858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37349035858&partnerID=8YFLogxK

U2 - 10.1002/ijc.23064

DO - 10.1002/ijc.23064

M3 - Article

C2 - 17764109

AN - SCOPUS:37349035858

VL - 122

SP - 609

EP - 613

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -