Nutrient dietary patterns and the risk of breast and ovarian cancers

Valeria Edefonti, Adriano Decarli, Carlo La Vecchia, Cristina Bosetti, Giorgia Randi, Silvia Franceschi, Luigino Dal Maso, Monica Ferraroni

Research output: Contribution to journalArticlepeer-review

Abstract

The issue of diet and breast and ovarian cancers has been considered in terms of foods and nutrients, but rarely in terms of dietary patterns. We examined the associations between dietary patterns and breast and ovarian cancers in 2 Italian multicentric case-control studies. Cases were 2,569 breast cancers and 1,031 ovarian cancers hospitalized in 4 Italian areas between 1991 and 1999. Controls were 3,413 women from the same hospital network. Dietary habits were investigated through a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals (CI) for both cancers were estimated using unconditional multiple logistic regression models on quartiles of factor scores and continuous factor scores. We identified 4 major dietary patterns named Animal products, Vitamins and fiber, Unsaturated fats and Starch-rich. The animal products pattern and the unsaturated fats pattern were inversely associated with breast cancer (OR = 0.74, 95% CI: 0.61-0.91 and OR = 0.83, 95% CI: 0.68-1.00, respectively, for the highest consumption quartile), whereas the starch-rich pattern was directly associated with it (OR = 1.34, 95% CI: 1.10-1.65). The vitamins and fiber pattern was inversely associated with ovarian cancer (OR = 0.77, 95% CI: 0.61-0.98), whereas the starch-rich pattern was directly associated with it (OR = 1.85, 95% CI: 1.37-2.48). In conclusion, the starch-rich pattern is potentially an unfavorable indicator of risk for both breast and ovarian cancers, while the animal products and the vitamins and fiber patterns may be associated with a reduced risk of breast and ovarian cancers, respectively.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalInternational Journal of Cancer
Volume122
Issue number3
DOIs
Publication statusPublished - Feb 1 2008

Keywords

  • Breast cancer
  • Dietary patterns
  • Factor analysis
  • Nutrients
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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