Nutrient dietary patterns and the risk of colorectal cancer: A case-control study from Italy

Francesca Bravi, Valeria Edefonti, Cristina Bosetti, Renato Talamini, Maurizio Montella, Attilio Giacosa, Silvia Franceschi, Eva Negri, Monica Ferraroni, Carlo La Vecchia, Adriano Decarli

Research output: Contribution to journalArticle

Abstract

Objective: The role of diet on colorectal cancer has been considered in terms of single foods and nutrients, but less frequently in terms of dietary patterns. Methods: Data were derived from an Italian case-control study, including 1,225 subjects with cancer of the colon, 728 subjects with rectal cancer, and 4,154 hospital controls. We identified dietary patterns on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals for both cancers were estimated using unconditional multiple logistic regression. Results: We identified 5 major dietary patterns. Direct associations were observed between the Starch-rich pattern and both cancer of the colon (OR = 1.68) and of the rectum (OR = 1.74). Inverse relationships were found between the Vitamins and fiber pattern and rectal cancer (OR = 0.61), between the Unsaturated fats (animal source) and the Unsaturated fats (vegetable source) and cancer of the colon (OR = 0.80 and OR = 0.79, respectively). No other significant association was found. Conclusions: The Starch-rich pattern is potentially an unfavorable indicator of risk for both colon and rectal cancer, whereas the Vitamins and fiber pattern is associated with a reduced risk of rectal cancer and the Unsaturated fats patterns with a reduced risk of colon cancer.

Original languageEnglish
Pages (from-to)1911-1918
Number of pages8
JournalCancer Causes and Control
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2010

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Italy
Case-Control Studies
Colorectal Neoplasms
Colonic Neoplasms
Odds Ratio
Unsaturated Fats
Rectal Neoplasms
Food
Vitamins
Starch
Principal Component Analysis
Rectum
Vegetables
Statistical Factor Analysis
Logistic Models
Confidence Intervals
Diet
Neoplasms

Keywords

  • Case-control study
  • Colorectal cancer
  • Dietary patterns
  • Factor analysis
  • Nutrients

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Nutrient dietary patterns and the risk of colorectal cancer : A case-control study from Italy. / Bravi, Francesca; Edefonti, Valeria; Bosetti, Cristina; Talamini, Renato; Montella, Maurizio; Giacosa, Attilio; Franceschi, Silvia; Negri, Eva; Ferraroni, Monica; La Vecchia, Carlo; Decarli, Adriano.

In: Cancer Causes and Control, Vol. 21, No. 11, 11.2010, p. 1911-1918.

Research output: Contribution to journalArticle

Bravi, F, Edefonti, V, Bosetti, C, Talamini, R, Montella, M, Giacosa, A, Franceschi, S, Negri, E, Ferraroni, M, La Vecchia, C & Decarli, A 2010, 'Nutrient dietary patterns and the risk of colorectal cancer: A case-control study from Italy', Cancer Causes and Control, vol. 21, no. 11, pp. 1911-1918. https://doi.org/10.1007/s10552-010-9619-1
Bravi, Francesca ; Edefonti, Valeria ; Bosetti, Cristina ; Talamini, Renato ; Montella, Maurizio ; Giacosa, Attilio ; Franceschi, Silvia ; Negri, Eva ; Ferraroni, Monica ; La Vecchia, Carlo ; Decarli, Adriano. / Nutrient dietary patterns and the risk of colorectal cancer : A case-control study from Italy. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 11. pp. 1911-1918.
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