Nutrient intake and serum cytokine pattern in elderly people with heart failure

Girolamo Catapano, Claudio Pedone, Eleonora Nunziata, Alessandro Zizzo, Andrea Passantino, Raffaele Antonelli Incalzi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Heart failure (HF) is frequently complicated by malnutrition. We estimated nutrient intake in HF patients and evaluated the correlation between serum cytokines and dietary pattern. Methods: We studied 124 elderly (≥ 60 years) patients with severe HF (N = 62) or without HF (controls, N = 62), matched for age and sex. Nutritional data were obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. We compared the intake of macro- and micronutrients in the two groups; in the HF group nutritional intake was correlated with serum cytokines. Results: HF patients had a lower energy intake (26.8 Kcal/Kg of ideal weight vs. 37.3 Kcal /Kg ideal weight in controls, P <0.001) due to a lower intake of all macronutrients. The energy intake was lower than the recommended (30 Kcal/Kg of ideal body weight) in 72% of HF and 34% of the controls. The intake of several minerals and vitamins was inferior to the recommended dietary allowance (RDA) in most participants. Those HF patients with a caloric intake below the median (22.6 Kcal/Kg ideal weight) did not differ substantially from those with higher caloric intake with regard to age, functional characteristics, and lean body mass as expressed by the mid-arm muscle circumference, however, they had a higher concentration of IL4 (61.5 pg/ml vs. 37.7 pg/ml, P = 0.075) and of IL10 (6.32 pg/ml vs. 2.06 pg/ml, P = 0.046). Conclusions: Nutritional intake is frequently inadequate in patients with severe HF. Our results suggest that some interleukins might affect caloric intake in patients with HF.

Original languageEnglish
Pages (from-to)428-434
Number of pages7
JournalEuropean Journal of Heart Failure
Volume10
Issue number4
DOIs
Publication statusPublished - Apr 2008

Fingerprint

Heart Failure
Cytokines
Food
Energy Intake
Serum
Weights and Measures
Recommended Dietary Allowances
Ideal Body Weight
Micronutrients
Interleukins
Vitamins
Malnutrition
Interleukin-4
Interleukin-10
Minerals
Muscles
Neoplasms

Keywords

  • Elderly
  • Heart failure
  • Nutrition

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Nutrient intake and serum cytokine pattern in elderly people with heart failure. / Catapano, Girolamo; Pedone, Claudio; Nunziata, Eleonora; Zizzo, Alessandro; Passantino, Andrea; Incalzi, Raffaele Antonelli.

In: European Journal of Heart Failure, Vol. 10, No. 4, 04.2008, p. 428-434.

Research output: Contribution to journalArticle

Catapano, Girolamo ; Pedone, Claudio ; Nunziata, Eleonora ; Zizzo, Alessandro ; Passantino, Andrea ; Incalzi, Raffaele Antonelli. / Nutrient intake and serum cytokine pattern in elderly people with heart failure. In: European Journal of Heart Failure. 2008 ; Vol. 10, No. 4. pp. 428-434.
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abstract = "Background: Heart failure (HF) is frequently complicated by malnutrition. We estimated nutrient intake in HF patients and evaluated the correlation between serum cytokines and dietary pattern. Methods: We studied 124 elderly (≥ 60 years) patients with severe HF (N = 62) or without HF (controls, N = 62), matched for age and sex. Nutritional data were obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. We compared the intake of macro- and micronutrients in the two groups; in the HF group nutritional intake was correlated with serum cytokines. Results: HF patients had a lower energy intake (26.8 Kcal/Kg of ideal weight vs. 37.3 Kcal /Kg ideal weight in controls, P <0.001) due to a lower intake of all macronutrients. The energy intake was lower than the recommended (30 Kcal/Kg of ideal body weight) in 72{\%} of HF and 34{\%} of the controls. The intake of several minerals and vitamins was inferior to the recommended dietary allowance (RDA) in most participants. Those HF patients with a caloric intake below the median (22.6 Kcal/Kg ideal weight) did not differ substantially from those with higher caloric intake with regard to age, functional characteristics, and lean body mass as expressed by the mid-arm muscle circumference, however, they had a higher concentration of IL4 (61.5 pg/ml vs. 37.7 pg/ml, P = 0.075) and of IL10 (6.32 pg/ml vs. 2.06 pg/ml, P = 0.046). Conclusions: Nutritional intake is frequently inadequate in patients with severe HF. Our results suggest that some interleukins might affect caloric intake in patients with HF.",
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AU - Catapano, Girolamo

AU - Pedone, Claudio

AU - Nunziata, Eleonora

AU - Zizzo, Alessandro

AU - Passantino, Andrea

AU - Incalzi, Raffaele Antonelli

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N2 - Background: Heart failure (HF) is frequently complicated by malnutrition. We estimated nutrient intake in HF patients and evaluated the correlation between serum cytokines and dietary pattern. Methods: We studied 124 elderly (≥ 60 years) patients with severe HF (N = 62) or without HF (controls, N = 62), matched for age and sex. Nutritional data were obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. We compared the intake of macro- and micronutrients in the two groups; in the HF group nutritional intake was correlated with serum cytokines. Results: HF patients had a lower energy intake (26.8 Kcal/Kg of ideal weight vs. 37.3 Kcal /Kg ideal weight in controls, P <0.001) due to a lower intake of all macronutrients. The energy intake was lower than the recommended (30 Kcal/Kg of ideal body weight) in 72% of HF and 34% of the controls. The intake of several minerals and vitamins was inferior to the recommended dietary allowance (RDA) in most participants. Those HF patients with a caloric intake below the median (22.6 Kcal/Kg ideal weight) did not differ substantially from those with higher caloric intake with regard to age, functional characteristics, and lean body mass as expressed by the mid-arm muscle circumference, however, they had a higher concentration of IL4 (61.5 pg/ml vs. 37.7 pg/ml, P = 0.075) and of IL10 (6.32 pg/ml vs. 2.06 pg/ml, P = 0.046). Conclusions: Nutritional intake is frequently inadequate in patients with severe HF. Our results suggest that some interleukins might affect caloric intake in patients with HF.

AB - Background: Heart failure (HF) is frequently complicated by malnutrition. We estimated nutrient intake in HF patients and evaluated the correlation between serum cytokines and dietary pattern. Methods: We studied 124 elderly (≥ 60 years) patients with severe HF (N = 62) or without HF (controls, N = 62), matched for age and sex. Nutritional data were obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. We compared the intake of macro- and micronutrients in the two groups; in the HF group nutritional intake was correlated with serum cytokines. Results: HF patients had a lower energy intake (26.8 Kcal/Kg of ideal weight vs. 37.3 Kcal /Kg ideal weight in controls, P <0.001) due to a lower intake of all macronutrients. The energy intake was lower than the recommended (30 Kcal/Kg of ideal body weight) in 72% of HF and 34% of the controls. The intake of several minerals and vitamins was inferior to the recommended dietary allowance (RDA) in most participants. Those HF patients with a caloric intake below the median (22.6 Kcal/Kg ideal weight) did not differ substantially from those with higher caloric intake with regard to age, functional characteristics, and lean body mass as expressed by the mid-arm muscle circumference, however, they had a higher concentration of IL4 (61.5 pg/ml vs. 37.7 pg/ml, P = 0.075) and of IL10 (6.32 pg/ml vs. 2.06 pg/ml, P = 0.046). Conclusions: Nutritional intake is frequently inadequate in patients with severe HF. Our results suggest that some interleukins might affect caloric intake in patients with HF.

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