Nutrient intakes, nutritional patterns and the risk of liver cirrhosis: An explorative case-control study

Giovanni Corrao, Antonella Zambon, Vinccnzo Bagnardi, Sarino Aricò, Carmelina Loguercio, Amleto D'amicis, D. Morelli, M. R. Moscatello, G. F. Stefanini, R. Chiesa, F. Donato, V. Tomasoni, V. Guglielmini, O. G. Manghisi, J. Petruzzi, L. Boncinelli, M. Bocchia, P. Ribotto, E. Canevelli, L. IsaM. Moriglioni, G. F. Sardi, M. Monica, [No Value] Fasoli, [No Value] Baldacci, G. Andri, G. Migliosi, A. Ajello, M. A. Freni, A. Spadaro, M. Gravina, G. Longo, C. Mangano, A. Silvani, R. Bottelli, G. Fiorelli, S. Fargion, Feo De Feo, A. Ascione, M. De Luca, A. Galeota Lanza, G. Del Vecchio Blanco, A. Federico, C. Loguercio, P. Burra, D. Mioni, R. Naccarato, F. Guarnone, C. Pallavicini, G. Vittadini, S. Aricò, M. Salvagnini

Research output: Contribution to journalArticle

Abstract

Several experimental studies have suggested that specific nutrients might play a role on the risk of liver damage. Nevertheless, few epidemiological studies have evaluated the role of diet on the risk of symptomatic liver cirrhosis, giving contradictory results. To evaluate the role of the intake of nutritional factors and dietary patterns on the risk of symptomatic liver cirrhosis and to examine their combined action with alcohol consumption we used data from the Italian Study on Liver Cirrhosis Determinants project. From 1994 to 1998 all the consecutive cirrhotic inpatients admitted to 19 Italian collaborative hospitals for signs of liver decompensation in whom the diagnosis of liver cirrhosis was made for the first time (259 cases) and one or two gender, age and area of residence matched individuals (416 controls) were recruited. Data on lifetime alcohol intake, usual consumption of 191 food items and on markers of hepatitis B and C viral infection were collected. The analysis of principal components identified a nutritional pattern positively correlated with vegetable and fruit intakes and negatively with animal and no-fruit sugar products. With respect to abstainers, relative risks in consumers of use ≤25 and ≥51g/day of alcohol increased from 0.4 [95% confidence interval 0.0, 5.9] to 9.3 [1.3, 69.0] and from 2.1 [1.1, 4.2] to 18.1 [2.8, 118.3] for the lowest and the highest value of this nutritional pattern, respectively. Diet might therefore modulate the damaging effect of alcohol on the liver.

Original languageEnglish
Pages (from-to)861-869
Number of pages9
JournalEuropean Journal of Epidemiology
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Liver Cirrhosis
Case-Control Studies
Food
Alcohols
Liver
Fruit
Diet
Nutritive Value
Virus Diseases
Hepatitis C
Principal Component Analysis
Hepatitis B
Alcohol Drinking
Vegetables
Inpatients
Epidemiologic Studies
Confidence Intervals

Keywords

  • Alcohol drinking
  • Diet
  • Hepatitis B virus
  • Hepatitis C virus
  • Liver cirrhosis
  • Nutritional factors

ASJC Scopus subject areas

  • Epidemiology

Cite this

Nutrient intakes, nutritional patterns and the risk of liver cirrhosis : An explorative case-control study. / Corrao, Giovanni; Zambon, Antonella; Bagnardi, Vinccnzo; Aricò, Sarino; Loguercio, Carmelina; D'amicis, Amleto; Morelli, D.; Moscatello, M. R.; Stefanini, G. F.; Chiesa, R.; Donato, F.; Tomasoni, V.; Guglielmini, V.; Manghisi, O. G.; Petruzzi, J.; Boncinelli, L.; Bocchia, M.; Ribotto, P.; Canevelli, E.; Isa, L.; Moriglioni, M.; Sardi, G. F.; Monica, M.; Fasoli, [No Value]; Baldacci, [No Value]; Andri, G.; Migliosi, G.; Ajello, A.; Freni, M. A.; Spadaro, A.; Gravina, M.; Longo, G.; Mangano, C.; Silvani, A.; Bottelli, R.; Fiorelli, G.; Fargion, S.; De Feo, Feo; Ascione, A.; De Luca, M.; Galeota Lanza, A.; Del Vecchio Blanco, G.; Federico, A.; Loguercio, C.; Burra, P.; Mioni, D.; Naccarato, R.; Guarnone, F.; Pallavicini, C.; Vittadini, G.; Aricò, S.; Salvagnini, M.

In: European Journal of Epidemiology, Vol. 19, No. 9, 09.2004, p. 861-869.

Research output: Contribution to journalArticle

Corrao, G, Zambon, A, Bagnardi, V, Aricò, S, Loguercio, C, D'amicis, A, Morelli, D, Moscatello, MR, Stefanini, GF, Chiesa, R, Donato, F, Tomasoni, V, Guglielmini, V, Manghisi, OG, Petruzzi, J, Boncinelli, L, Bocchia, M, Ribotto, P, Canevelli, E, Isa, L, Moriglioni, M, Sardi, GF, Monica, M, Fasoli, NV, Baldacci, NV, Andri, G, Migliosi, G, Ajello, A, Freni, MA, Spadaro, A, Gravina, M, Longo, G, Mangano, C, Silvani, A, Bottelli, R, Fiorelli, G, Fargion, S, De Feo, F, Ascione, A, De Luca, M, Galeota Lanza, A, Del Vecchio Blanco, G, Federico, A, Loguercio, C, Burra, P, Mioni, D, Naccarato, R, Guarnone, F, Pallavicini, C, Vittadini, G, Aricò, S & Salvagnini, M 2004, 'Nutrient intakes, nutritional patterns and the risk of liver cirrhosis: An explorative case-control study', European Journal of Epidemiology, vol. 19, no. 9, pp. 861-869. https://doi.org/10.1023/B:EJEP.0000040534.89451.d2
Corrao, Giovanni ; Zambon, Antonella ; Bagnardi, Vinccnzo ; Aricò, Sarino ; Loguercio, Carmelina ; D'amicis, Amleto ; Morelli, D. ; Moscatello, M. R. ; Stefanini, G. F. ; Chiesa, R. ; Donato, F. ; Tomasoni, V. ; Guglielmini, V. ; Manghisi, O. G. ; Petruzzi, J. ; Boncinelli, L. ; Bocchia, M. ; Ribotto, P. ; Canevelli, E. ; Isa, L. ; Moriglioni, M. ; Sardi, G. F. ; Monica, M. ; Fasoli, [No Value] ; Baldacci, [No Value] ; Andri, G. ; Migliosi, G. ; Ajello, A. ; Freni, M. A. ; Spadaro, A. ; Gravina, M. ; Longo, G. ; Mangano, C. ; Silvani, A. ; Bottelli, R. ; Fiorelli, G. ; Fargion, S. ; De Feo, Feo ; Ascione, A. ; De Luca, M. ; Galeota Lanza, A. ; Del Vecchio Blanco, G. ; Federico, A. ; Loguercio, C. ; Burra, P. ; Mioni, D. ; Naccarato, R. ; Guarnone, F. ; Pallavicini, C. ; Vittadini, G. ; Aricò, S. ; Salvagnini, M. / Nutrient intakes, nutritional patterns and the risk of liver cirrhosis : An explorative case-control study. In: European Journal of Epidemiology. 2004 ; Vol. 19, No. 9. pp. 861-869.
@article{160a614a7fbf441083bf5da58c72abea,
title = "Nutrient intakes, nutritional patterns and the risk of liver cirrhosis: An explorative case-control study",
abstract = "Several experimental studies have suggested that specific nutrients might play a role on the risk of liver damage. Nevertheless, few epidemiological studies have evaluated the role of diet on the risk of symptomatic liver cirrhosis, giving contradictory results. To evaluate the role of the intake of nutritional factors and dietary patterns on the risk of symptomatic liver cirrhosis and to examine their combined action with alcohol consumption we used data from the Italian Study on Liver Cirrhosis Determinants project. From 1994 to 1998 all the consecutive cirrhotic inpatients admitted to 19 Italian collaborative hospitals for signs of liver decompensation in whom the diagnosis of liver cirrhosis was made for the first time (259 cases) and one or two gender, age and area of residence matched individuals (416 controls) were recruited. Data on lifetime alcohol intake, usual consumption of 191 food items and on markers of hepatitis B and C viral infection were collected. The analysis of principal components identified a nutritional pattern positively correlated with vegetable and fruit intakes and negatively with animal and no-fruit sugar products. With respect to abstainers, relative risks in consumers of use ≤25 and ≥51g/day of alcohol increased from 0.4 [95{\%} confidence interval 0.0, 5.9] to 9.3 [1.3, 69.0] and from 2.1 [1.1, 4.2] to 18.1 [2.8, 118.3] for the lowest and the highest value of this nutritional pattern, respectively. Diet might therefore modulate the damaging effect of alcohol on the liver.",
keywords = "Alcohol drinking, Diet, Hepatitis B virus, Hepatitis C virus, Liver cirrhosis, Nutritional factors",
author = "Giovanni Corrao and Antonella Zambon and Vinccnzo Bagnardi and Sarino Aric{\`o} and Carmelina Loguercio and Amleto D'amicis and D. Morelli and Moscatello, {M. R.} and Stefanini, {G. F.} and R. Chiesa and F. Donato and V. Tomasoni and V. Guglielmini and Manghisi, {O. G.} and J. Petruzzi and L. Boncinelli and M. Bocchia and P. Ribotto and E. Canevelli and L. Isa and M. Moriglioni and Sardi, {G. F.} and M. Monica and Fasoli, {[No Value]} and Baldacci, {[No Value]} and G. Andri and G. Migliosi and A. Ajello and Freni, {M. A.} and A. Spadaro and M. Gravina and G. Longo and C. Mangano and A. Silvani and R. Bottelli and G. Fiorelli and S. Fargion and {De Feo}, Feo and A. Ascione and {De Luca}, M. and {Galeota Lanza}, A. and {Del Vecchio Blanco}, G. and A. Federico and C. Loguercio and P. Burra and D. Mioni and R. Naccarato and F. Guarnone and C. Pallavicini and G. Vittadini and S. Aric{\`o} and M. Salvagnini",
year = "2004",
month = "9",
doi = "10.1023/B:EJEP.0000040534.89451.d2",
language = "English",
volume = "19",
pages = "861--869",
journal = "European Journal of Epidemiology",
issn = "0393-2990",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - Nutrient intakes, nutritional patterns and the risk of liver cirrhosis

T2 - An explorative case-control study

AU - Corrao, Giovanni

AU - Zambon, Antonella

AU - Bagnardi, Vinccnzo

AU - Aricò, Sarino

AU - Loguercio, Carmelina

AU - D'amicis, Amleto

AU - Morelli, D.

AU - Moscatello, M. R.

AU - Stefanini, G. F.

AU - Chiesa, R.

AU - Donato, F.

AU - Tomasoni, V.

AU - Guglielmini, V.

AU - Manghisi, O. G.

AU - Petruzzi, J.

AU - Boncinelli, L.

AU - Bocchia, M.

AU - Ribotto, P.

AU - Canevelli, E.

AU - Isa, L.

AU - Moriglioni, M.

AU - Sardi, G. F.

AU - Monica, M.

AU - Fasoli, [No Value]

AU - Baldacci, [No Value]

AU - Andri, G.

AU - Migliosi, G.

AU - Ajello, A.

AU - Freni, M. A.

AU - Spadaro, A.

AU - Gravina, M.

AU - Longo, G.

AU - Mangano, C.

AU - Silvani, A.

AU - Bottelli, R.

AU - Fiorelli, G.

AU - Fargion, S.

AU - De Feo, Feo

AU - Ascione, A.

AU - De Luca, M.

AU - Galeota Lanza, A.

AU - Del Vecchio Blanco, G.

AU - Federico, A.

AU - Loguercio, C.

AU - Burra, P.

AU - Mioni, D.

AU - Naccarato, R.

AU - Guarnone, F.

AU - Pallavicini, C.

AU - Vittadini, G.

AU - Aricò, S.

AU - Salvagnini, M.

PY - 2004/9

Y1 - 2004/9

N2 - Several experimental studies have suggested that specific nutrients might play a role on the risk of liver damage. Nevertheless, few epidemiological studies have evaluated the role of diet on the risk of symptomatic liver cirrhosis, giving contradictory results. To evaluate the role of the intake of nutritional factors and dietary patterns on the risk of symptomatic liver cirrhosis and to examine their combined action with alcohol consumption we used data from the Italian Study on Liver Cirrhosis Determinants project. From 1994 to 1998 all the consecutive cirrhotic inpatients admitted to 19 Italian collaborative hospitals for signs of liver decompensation in whom the diagnosis of liver cirrhosis was made for the first time (259 cases) and one or two gender, age and area of residence matched individuals (416 controls) were recruited. Data on lifetime alcohol intake, usual consumption of 191 food items and on markers of hepatitis B and C viral infection were collected. The analysis of principal components identified a nutritional pattern positively correlated with vegetable and fruit intakes and negatively with animal and no-fruit sugar products. With respect to abstainers, relative risks in consumers of use ≤25 and ≥51g/day of alcohol increased from 0.4 [95% confidence interval 0.0, 5.9] to 9.3 [1.3, 69.0] and from 2.1 [1.1, 4.2] to 18.1 [2.8, 118.3] for the lowest and the highest value of this nutritional pattern, respectively. Diet might therefore modulate the damaging effect of alcohol on the liver.

AB - Several experimental studies have suggested that specific nutrients might play a role on the risk of liver damage. Nevertheless, few epidemiological studies have evaluated the role of diet on the risk of symptomatic liver cirrhosis, giving contradictory results. To evaluate the role of the intake of nutritional factors and dietary patterns on the risk of symptomatic liver cirrhosis and to examine their combined action with alcohol consumption we used data from the Italian Study on Liver Cirrhosis Determinants project. From 1994 to 1998 all the consecutive cirrhotic inpatients admitted to 19 Italian collaborative hospitals for signs of liver decompensation in whom the diagnosis of liver cirrhosis was made for the first time (259 cases) and one or two gender, age and area of residence matched individuals (416 controls) were recruited. Data on lifetime alcohol intake, usual consumption of 191 food items and on markers of hepatitis B and C viral infection were collected. The analysis of principal components identified a nutritional pattern positively correlated with vegetable and fruit intakes and negatively with animal and no-fruit sugar products. With respect to abstainers, relative risks in consumers of use ≤25 and ≥51g/day of alcohol increased from 0.4 [95% confidence interval 0.0, 5.9] to 9.3 [1.3, 69.0] and from 2.1 [1.1, 4.2] to 18.1 [2.8, 118.3] for the lowest and the highest value of this nutritional pattern, respectively. Diet might therefore modulate the damaging effect of alcohol on the liver.

KW - Alcohol drinking

KW - Diet

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Liver cirrhosis

KW - Nutritional factors

UR - http://www.scopus.com/inward/record.url?scp=16644396154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16644396154&partnerID=8YFLogxK

U2 - 10.1023/B:EJEP.0000040534.89451.d2

DO - 10.1023/B:EJEP.0000040534.89451.d2

M3 - Article

C2 - 15499896

AN - SCOPUS:16644396154

VL - 19

SP - 861

EP - 869

JO - European Journal of Epidemiology

JF - European Journal of Epidemiology

SN - 0393-2990

IS - 9

ER -