Nutrients and Porphyria: An Intriguing Crosstalk

Research output: Contribution to journalReview articlepeer-review


Porphyria refers to a group of fascinating diseases from a metabolic and nutritional standpoint as it provides an example of how metabolic manipulation can be used for therapeutic purposes. It is characterized by defects in heme synthesis, particularly in the erythrocytes and liver. Specific enzymes involved in heme biosynthesis directly depend on adequate levels of vitamins and minerals in the tissues. Moreover, micronutrients that are required for producing succinyl CoA and other intermediates in the Krebs (TCA) cycle are indirectly necessary for heme metabolism. This review summarizes articles that describe the nutritional status, supplements intake, and dietary practices of patients affected by porphyria, paying special attention to the therapeutic use of nutrients that may help or hinder this group of diseases.

Original languageEnglish
Article number3462
JournalInternational Journal of Molecular Sciences
Issue number10
Publication statusPublished - May 14 2020


  • diet
  • genetic factors
  • iron metabolism
  • lipid and glucose metabolism
  • nutrients
  • nutrigenomics
  • personalized nutrition
  • porphyria

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


Dive into the research topics of 'Nutrients and Porphyria: An Intriguing Crosstalk'. Together they form a unique fingerprint.

Cite this