Nutrients and risk of prostate cancer

Jinfu Hu, Carlo La Vecchia, Laurrie Gibbons, Eva Negri, Les Mery

Research output: Contribution to journalArticle

Abstract

This study assesses the association between intake of protein, fats, cholesterol, and carbohydrates and the risk of prostate cancer (PCa). Between 1994 and 1997, in 8 Canadian provinces, mailed questionnaires were completed by 1,797 incident, histologically confirmed cases of PCa and 2,547 population controls. Information was collected on socioeconomic status, lifestyle habits, and diet. A 69-item food frequency questionnaire provided data on eating habits 2 yr before the study. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using unconditional logistic regression, including terms for sociodemographic factors, body mass index, alcohol, and total energy intake. Intake of trans fat was associated with the risk of PCa; the OR for the highest vs. the lowest quartile was 1.45 (95% CI = 1.16-1.81); the association was apparently stronger in subjects aged less than 65, normal weight men, and ever smokers. An increased risk was also observed with increasing intake of sucrose and disaccharides. In contrast, men in the highest quartile of cholesterol intake were at lower risk of PCa. No association was found with intake of total proteins, total fat, monounsaturated fats, polyunsaturated fats, monosaccharides, and total carbohydrates. The findings provide evidence that a diet low in trans fat could reduce PCa risk.

Original languageEnglish
Pages (from-to)710-718
Number of pages9
JournalNutrition and Cancer
Volume62
Issue number6
DOIs
Publication statusPublished - Aug 2010

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Prostatic Neoplasms
Fats
Food
Feeding Behavior
Odds Ratio
Cholesterol
Carbohydrates
Confidence Intervals
Population Control
Monosaccharides
Disaccharides
Energy Intake
Social Class
Sucrose
Life Style
Proteins
Body Mass Index
Logistic Models
Alcohols
Diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Oncology
  • Cancer Research

Cite this

Hu, J., La Vecchia, C., Gibbons, L., Negri, E., & Mery, L. (2010). Nutrients and risk of prostate cancer. Nutrition and Cancer, 62(6), 710-718. https://doi.org/10.1080/01635581003605953

Nutrients and risk of prostate cancer. / Hu, Jinfu; La Vecchia, Carlo; Gibbons, Laurrie; Negri, Eva; Mery, Les.

In: Nutrition and Cancer, Vol. 62, No. 6, 08.2010, p. 710-718.

Research output: Contribution to journalArticle

Hu, J, La Vecchia, C, Gibbons, L, Negri, E & Mery, L 2010, 'Nutrients and risk of prostate cancer', Nutrition and Cancer, vol. 62, no. 6, pp. 710-718. https://doi.org/10.1080/01635581003605953
Hu J, La Vecchia C, Gibbons L, Negri E, Mery L. Nutrients and risk of prostate cancer. Nutrition and Cancer. 2010 Aug;62(6):710-718. https://doi.org/10.1080/01635581003605953
Hu, Jinfu ; La Vecchia, Carlo ; Gibbons, Laurrie ; Negri, Eva ; Mery, Les. / Nutrients and risk of prostate cancer. In: Nutrition and Cancer. 2010 ; Vol. 62, No. 6. pp. 710-718.
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