Nutrigenomics: A case for the common soil between cardiovascular disease and cancer

Licia Iacoviello, Iolanda Santimone, Maria Carmela Latella, Giovanni Gaetano, Maria Benedetta Donati

Research output: Contribution to journalArticlepeer-review


The border between health and disease is often set by a complex equilibrium between two elements, genetics on one hand, lifestyle on the other, To know it better, means to give new weapons, often crucial, in the hands of the doctors and their patients. It also means to adjust therapies, to find out which drug is good for a patient and which prevention strategy will work better for him/her. Nutrigenomics is an approach to individualize or personalize food and nutrition, and ultimately health, by tailoring the food to the individual genotype. In this review, we present the interaction between certain genetic polymorphisms and diet and increased cardiovascular or cancer risk. It is, indeed, now clear that a large number of bioactive food components may provide risk or protection at several stages of both atherosclerosis and cancer formation processes. We are giving here few examples of gene-food interactions relevant for both the risk of cardiovascular disease and cancer, since a common soil could exist in the genesis of cardiovascular disease and of some types of cancer (mainly gastrointestinal tract and hormone-dependent).

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalGenes and Nutrition
Issue number1
Publication statusPublished - 2008


  • Cancer
  • Cardiovascular disease
  • Nutrigenomics
  • Polyunsaturated fatty acids

ASJC Scopus subject areas

  • Genetics
  • Endocrinology, Diabetes and Metabolism


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