Nutrition and prevention of ischemic stroke: Present knowledge, limitations and future perspectives

P. Strazzullo, L. Scalfi, F. Branca, G. Cairella, F. Garbagnati, A. Siani, G. Barba, P. Rubba, G. Mancia

Research output: Contribution to journalArticle

Abstract

Stroke, particularly ischemic stroke, has a major impact on public health due to its high incidence, prevalence and rate of subsequent disability in Italy as in most industrialised countries. Apart from age, many modifiable factors, such as hypertension, smoking, diabetes, dyslipidemia, obesity, physical inactivity, alcohol abuse and hyperhomocysteinemia, have been recognised as playing a role in the pathogenesis of this disease. While appropriate pharmacological therapy has proven effective in the prevention of stroke in particular categories of patients, most of the above mentioned predisposing conditions are amenable to be affected by nutrition. Unequivocal demonstration of a protective or adverse role of single foods and nutrients against the risk of stroke has been however difficult to achieve due to confounding by biological variability, methodological inadequacies in the assessment of individual nutritional habits and difficulty to carry out long-term randomised controlled trials in the nutritional area. Notwithstanding, in several cases, causal relationships could be inferred from case-control and cohort studies in the presence of plausible and reproducible associations, evidence of dose-dependent effects and consistency in the results of different studies. The aim of this paper was to review present knowledge and highlight limitations and future perspectives about the role of nutrition in the prevention of ischemic stroke.

Original languageEnglish
Pages (from-to)97-114
Number of pages18
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume14
Issue number2
DOIs
Publication statusPublished - Apr 2004

Fingerprint

stroke
Stroke
nutrition
Food
Hyperhomocysteinemia
Nutrition Assessment
hyperlipidemia
alcohol abuse
Dyslipidemias
case-control studies
cohort studies
Developed Countries
developed countries
Italy
hypertension
Alcoholism
Habits
diabetes
Case-Control Studies
public health

Keywords

  • Foods
  • Ischemic stroke
  • Nutrients
  • Nutrition
  • Prevention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Nutrition and prevention of ischemic stroke : Present knowledge, limitations and future perspectives. / Strazzullo, P.; Scalfi, L.; Branca, F.; Cairella, G.; Garbagnati, F.; Siani, A.; Barba, G.; Rubba, P.; Mancia, G.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 14, No. 2, 04.2004, p. 97-114.

Research output: Contribution to journalArticle

Strazzullo, P, Scalfi, L, Branca, F, Cairella, G, Garbagnati, F, Siani, A, Barba, G, Rubba, P & Mancia, G 2004, 'Nutrition and prevention of ischemic stroke: Present knowledge, limitations and future perspectives', Nutrition, Metabolism and Cardiovascular Diseases, vol. 14, no. 2, pp. 97-114. https://doi.org/10.1016/S0939-4753(04)80017-6
Strazzullo, P. ; Scalfi, L. ; Branca, F. ; Cairella, G. ; Garbagnati, F. ; Siani, A. ; Barba, G. ; Rubba, P. ; Mancia, G. / Nutrition and prevention of ischemic stroke : Present knowledge, limitations and future perspectives. In: Nutrition, Metabolism and Cardiovascular Diseases. 2004 ; Vol. 14, No. 2. pp. 97-114.
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