Nutrition, nitrogen requirements, exercise and chemotherapy-induced toxicity in cancer patients. A puzzle of contrasting truths?

Vincenzo Flati, Giovanni Corsetti, Evasio Pasini, Anna Rufo, Claudia Romano, Francesco Saverio Dioguardi

Research output: Contribution to journalArticlepeer-review

Abstract

Amino acids can modulate cell metabolism and control cell fate by regulating cell survival and cell death. The molecular mechanisms involved are mediated by the mTOR complexes mTORC1 and mTORC2 activity. These complexes are finely regulated and the continuous advancement of the knowledge on their composition and function is revealing that their balance may represent the condition that determines the cell fate. This is important for normal healthy cells but it is becoming clear, and it is even more important, that the balance of the mTORCs activity may also condition the cell fate of cancer cells. Here, we discuss the evidences supporting the amino acids supplementation as a cancer fighting weapon and a possible strategy to counteract the myocyte toxicity associated with chemotherapy, possibly by tipping the balance of mTORCs activity.

Original languageEnglish
Pages (from-to)89-100
Number of pages12
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Amino acids
  • Cancer
  • Chemotherapy
  • Exercise
  • Heart doxorubicin
  • MTOR
  • Nutrition

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

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