Abstract
The immune system is a highly integrated network of cells sensitive to a number of environmental factors. Interestingly, recent years have seen a dramatic increase in our understanding of how diet makes a crucial contribution to human health, affecting the immune system, secretion of adipocytokines and metabolic pathways. Recent experimental evidence indicates that diet and its components are able to profoundly influence immune responses, thus affecting the development of inflammatory and autoimmune diseases. This review aims to discuss some of the main topics concerning the impact of nutrients and their relative composition on immune cell development and function that may be particularly important for regulating the balance between inflammatory and tolerogenic processes. We also highlight the effects of diet on commensal bacteria and how changes in the composition of the microbiota alter intestinal and systemic immune homeostasis. Finally, we summarize the effects of dietary compounds on epigenetic mechanisms involved in the regulation of several immune related genes.
| Original language | English |
|---|---|
| Pages (from-to) | 300-309 |
| Number of pages | 10 |
| Journal | Seminars in Immunology |
| Volume | 27 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 1 2015 |
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Keywords
- Dietary components
- Gut microbiota
- Immune function
- Nutriepigenomics
- Nutrition
- Obesity
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Nutritional control of immunity : Balancing the metabolic requirements with an appropriate immune function. / De Rosa, Veronica; Galgani, Mario; Santopaolo, Marianna; Colamatteo, Alessandra; Laccetti, Roberta; Matarese, Giuseppe.
In: Seminars in Immunology, Vol. 27, No. 5, 01.09.2015, p. 300-309.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nutritional control of immunity
T2 - Balancing the metabolic requirements with an appropriate immune function
AU - De Rosa, Veronica
AU - Galgani, Mario
AU - Santopaolo, Marianna
AU - Colamatteo, Alessandra
AU - Laccetti, Roberta
AU - Matarese, Giuseppe
PY - 2015/9/1
Y1 - 2015/9/1
N2 - The immune system is a highly integrated network of cells sensitive to a number of environmental factors. Interestingly, recent years have seen a dramatic increase in our understanding of how diet makes a crucial contribution to human health, affecting the immune system, secretion of adipocytokines and metabolic pathways. Recent experimental evidence indicates that diet and its components are able to profoundly influence immune responses, thus affecting the development of inflammatory and autoimmune diseases. This review aims to discuss some of the main topics concerning the impact of nutrients and their relative composition on immune cell development and function that may be particularly important for regulating the balance between inflammatory and tolerogenic processes. We also highlight the effects of diet on commensal bacteria and how changes in the composition of the microbiota alter intestinal and systemic immune homeostasis. Finally, we summarize the effects of dietary compounds on epigenetic mechanisms involved in the regulation of several immune related genes.
AB - The immune system is a highly integrated network of cells sensitive to a number of environmental factors. Interestingly, recent years have seen a dramatic increase in our understanding of how diet makes a crucial contribution to human health, affecting the immune system, secretion of adipocytokines and metabolic pathways. Recent experimental evidence indicates that diet and its components are able to profoundly influence immune responses, thus affecting the development of inflammatory and autoimmune diseases. This review aims to discuss some of the main topics concerning the impact of nutrients and their relative composition on immune cell development and function that may be particularly important for regulating the balance between inflammatory and tolerogenic processes. We also highlight the effects of diet on commensal bacteria and how changes in the composition of the microbiota alter intestinal and systemic immune homeostasis. Finally, we summarize the effects of dietary compounds on epigenetic mechanisms involved in the regulation of several immune related genes.
KW - Dietary components
KW - Gut microbiota
KW - Immune function
KW - Nutriepigenomics
KW - Nutrition
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84954197205&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954197205&partnerID=8YFLogxK
U2 - 10.1016/j.smim.2015.10.001
DO - 10.1016/j.smim.2015.10.001
M3 - Article
AN - SCOPUS:84954197205
VL - 27
SP - 300
EP - 309
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 5
ER -