Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults: A Systematic Review

Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Angela Lamanna, Roberta Stallone, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza

Research output: Contribution to journalArticle

Abstract

The link diet-cognitive function/dementia has been largely investigated in observational studies; however, there was a lack of evidence from randomized clinical trials (RCTs) on the prevention of late-life cognitive disorders though dietary intervention in cognitively healthy older adults. In the present article, we systematically reviewed RCTs published in the last four years (2014-2017) exploring nutritional intervention efficacy in preventing the onset of late-life cognitive disorders and dementia in cognitively healthy subjects aged 60 years and older using different levels of investigation (i.e., dietary pattern changes/medical food/nutraceutical supplementation/multidomain approach and dietary macro- and micronutrient approaches) as well as possible underlying mechanisms of nutritional prevention. From the 35 included RCTs, there was moderate evidence that intervention through dietary pattern changes, medical food/nutraceutical supplementation, and multidomain approach improved specific cognitive domains or cognitive-related blood biomarkers. There was high evidence that protein supplementation improved specific cognitive domains or functional status in prefrail older adults without effect.

Original languageEnglish
Pages (from-to)S229-S254
JournalJournal of Alzheimer's disease : JAD
Volume64
Issue numbers1
DOIs
Publication statusPublished - 2018

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Solfrizzi, V., Agosti, P., Lozupone, M., Custodero, C., Schilardi, A., Valiani, V., Sardone, R., Dibello, V., Di Lena, L., Lamanna, A., Stallone, R., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Sabbà, C., Logroscino, G., & Panza, F. (2018). Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults: A Systematic Review. Journal of Alzheimer's disease : JAD, 64(s1), S229-S254. https://doi.org/10.3233/JAD-179940