Nutritional interventions and cognitive-related outcomes in patients with late-life cognitive disorders: A systematic review

Vincenzo Solfrizzi, Pasquale Agosti, Madia Lozupone, Carlo Custodero, Andrea Schilardi, Vincenzo Valiani, Andrea Santamato, Rodolfo Sardone, Vittorio Dibello, Luca Di Lena, Roberta Stallone, Maurizio Ranieri, Antonello Bellomo, Antonio Greco, Antonio Daniele, Davide Seripa, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza

Research output: Contribution to journalReview articlepeer-review


There have been a large number of observational studies on the impact of nutrition on neuroprotection, however, there was a lack of evidence from randomized clinical trials (RCTs). In the present systematic review, from the 32 included RCTs published in the last four years (2014–2017) in patients aged 60 years and older with different late-life cognitive disorders, nutritional intervention through medical food/nutraceutical supplementation and multidomain approach improved magnetic resonance imaging findings and other cognitive-related biomarkers, but without clear effect on cognition in mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). Antioxidant-rich foods (nuts, grapes, cherries) and fatty acid supplementation, mainly n-3 polyunsaturated fatty acids (PUFA), improved specific cognitive domains and cognitive-related outcomes in MCI, mild-to-moderate dementia, and AD. Antioxidant vitamin and trace element supplementations improved only cognitive-related outcomes and biomarkers, high-dose B vitamin supplementation in AD and MCI patients improved cognitive outcomes in the subjects with a high baseline plasma n-3 PUFA, while folic acid supplementation had positive impact on specific cognitive domains in those with high homocysteine.

Original languageEnglish
Pages (from-to)480-498
Number of pages19
JournalNeuroscience and Biobehavioral Reviews
Publication statusPublished - Dec 1 2018


  • Alzheimer's disease
  • Dementia
  • Macronutrients
  • Medical food
  • Micronutrients
  • Nutraceuticals

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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