Abstract
Digestive function and nutritional status were studied in 24 patients who underwent pancreatoduodenectomy with suppression of exocrine pancreatic function by Neoprene injection. The ability of enzyme replacement (pancrelipase enteric-coated microspheres) in correcting steaorrhoea was assessed in association with different dietary fat intakes (isocaloric diets of 2,400 Kcal/day). In the early postoperative period, faecal fat excretion was on average 14.2±6.6g/day in 14 patients who received a 70 g/day fat diet, while it was 26.9±13.7 g/day in 10 patients treated with a fat-load diet (100 g/day) (p <0.01). In all patients, the mean values of nutritional indices were on average at the lower limits of normal, and body weight was 89.1% of usual body weight (UBW). Patients were discharged on a low-fat diet (50 g/day). Six months after surgery, the average body weight rose to 93.8% of UBW (p <0.01) and eight patients reached their UBW. All nutritional indicators showed a significant increase. In 10 patients faecal fat excretion was controlled while continuing on low-fat diet: steatorrhoea further decreased to 8.3±3.9 g/day (p <0.01 vs 70 g diet) and 5 patients were within the normal range (<7 g/day). The coefficient of fat absorpotion was 73.1%, 79.9% and 83.4% with a 100, 70 and 50 g/day dietary fat intake, respectively (r=-.372, p <0.05). This indicates that a larger proportion of fat is absorbed when a smaller intake in given. In conclusion, a low-fat diet combined with enzyme replacement allowed the correction of steatorrhoea and the return to a good nutritional status.
| Original language | English |
|---|---|
| Title of host publication | Journal of Clinical Nutrition and Gastroenterology |
| Pages | 137-142 |
| Number of pages | 6 |
| Volume | 6 |
| Edition | 3 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Gastroenterology
- Nutrition and Dietetics
Cite this
Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. / Braga, M.; Dal Cin, S.; Zerbi, A.; Cristallo, M.; Di Carlo, V.
Journal of Clinical Nutrition and Gastroenterology. Vol. 6 3. ed. 1991. p. 137-142.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency
AU - Braga, M.
AU - Dal Cin, S.
AU - Zerbi, A.
AU - Cristallo, M.
AU - Di Carlo, V.
PY - 1991
Y1 - 1991
N2 - Digestive function and nutritional status were studied in 24 patients who underwent pancreatoduodenectomy with suppression of exocrine pancreatic function by Neoprene injection. The ability of enzyme replacement (pancrelipase enteric-coated microspheres) in correcting steaorrhoea was assessed in association with different dietary fat intakes (isocaloric diets of 2,400 Kcal/day). In the early postoperative period, faecal fat excretion was on average 14.2±6.6g/day in 14 patients who received a 70 g/day fat diet, while it was 26.9±13.7 g/day in 10 patients treated with a fat-load diet (100 g/day) (p <0.01). In all patients, the mean values of nutritional indices were on average at the lower limits of normal, and body weight was 89.1% of usual body weight (UBW). Patients were discharged on a low-fat diet (50 g/day). Six months after surgery, the average body weight rose to 93.8% of UBW (p <0.01) and eight patients reached their UBW. All nutritional indicators showed a significant increase. In 10 patients faecal fat excretion was controlled while continuing on low-fat diet: steatorrhoea further decreased to 8.3±3.9 g/day (p <0.01 vs 70 g diet) and 5 patients were within the normal range (<7 g/day). The coefficient of fat absorpotion was 73.1%, 79.9% and 83.4% with a 100, 70 and 50 g/day dietary fat intake, respectively (r=-.372, p <0.05). This indicates that a larger proportion of fat is absorbed when a smaller intake in given. In conclusion, a low-fat diet combined with enzyme replacement allowed the correction of steatorrhoea and the return to a good nutritional status.
AB - Digestive function and nutritional status were studied in 24 patients who underwent pancreatoduodenectomy with suppression of exocrine pancreatic function by Neoprene injection. The ability of enzyme replacement (pancrelipase enteric-coated microspheres) in correcting steaorrhoea was assessed in association with different dietary fat intakes (isocaloric diets of 2,400 Kcal/day). In the early postoperative period, faecal fat excretion was on average 14.2±6.6g/day in 14 patients who received a 70 g/day fat diet, while it was 26.9±13.7 g/day in 10 patients treated with a fat-load diet (100 g/day) (p <0.01). In all patients, the mean values of nutritional indices were on average at the lower limits of normal, and body weight was 89.1% of usual body weight (UBW). Patients were discharged on a low-fat diet (50 g/day). Six months after surgery, the average body weight rose to 93.8% of UBW (p <0.01) and eight patients reached their UBW. All nutritional indicators showed a significant increase. In 10 patients faecal fat excretion was controlled while continuing on low-fat diet: steatorrhoea further decreased to 8.3±3.9 g/day (p <0.01 vs 70 g diet) and 5 patients were within the normal range (<7 g/day). The coefficient of fat absorpotion was 73.1%, 79.9% and 83.4% with a 100, 70 and 50 g/day dietary fat intake, respectively (r=-.372, p <0.05). This indicates that a larger proportion of fat is absorbed when a smaller intake in given. In conclusion, a low-fat diet combined with enzyme replacement allowed the correction of steatorrhoea and the return to a good nutritional status.
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M3 - Chapter
VL - 6
SP - 137
EP - 142
BT - Journal of Clinical Nutrition and Gastroenterology
ER -