Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency

M. Braga, S. Dal Cin, A. Zerbi, M. Cristallo, V. Di Carlo

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Digestive function and nutritional status were studied in 24 patients who underwent pancreatoduodenectomy with suppression of exocrine pancreatic function by Neoprene injection. The ability of enzyme replacement (pancrelipase enteric-coated microspheres) in correcting steaorrhoea was assessed in association with different dietary fat intakes (isocaloric diets of 2,400 Kcal/day). In the early postoperative period, faecal fat excretion was on average 14.2±6.6g/day in 14 patients who received a 70 g/day fat diet, while it was 26.9±13.7 g/day in 10 patients treated with a fat-load diet (100 g/day) (p <0.01). In all patients, the mean values of nutritional indices were on average at the lower limits of normal, and body weight was 89.1% of usual body weight (UBW). Patients were discharged on a low-fat diet (50 g/day). Six months after surgery, the average body weight rose to 93.8% of UBW (p <0.01) and eight patients reached their UBW. All nutritional indicators showed a significant increase. In 10 patients faecal fat excretion was controlled while continuing on low-fat diet: steatorrhoea further decreased to 8.3±3.9 g/day (p <0.01 vs 70 g diet) and 5 patients were within the normal range (<7 g/day). The coefficient of fat absorpotion was 73.1%, 79.9% and 83.4% with a 100, 70 and 50 g/day dietary fat intake, respectively (r=-.372, p <0.05). This indicates that a larger proportion of fat is absorbed when a smaller intake in given. In conclusion, a low-fat diet combined with enzyme replacement allowed the correction of steatorrhoea and the return to a good nutritional status.

Original languageEnglish
Title of host publicationJournal of Clinical Nutrition and Gastroenterology
Pages137-142
Number of pages6
Volume6
Edition3
Publication statusPublished - 1991

Fingerprint

Exocrine Pancreatic Insufficiency
Fats
Fat-Restricted Diet
Body Weight
Diet
Steatorrhea
Dietary Fats
Nutritional Status
Pancrelipase
Neoprene
Ideal Body Weight
Nutrition Assessment
Pancreaticoduodenectomy
Enzymes
Microspheres
Postoperative Period
Reference Values
Injections

ASJC Scopus subject areas

  • Gastroenterology
  • Nutrition and Dietetics

Cite this

Braga, M., Dal Cin, S., Zerbi, A., Cristallo, M., & Di Carlo, V. (1991). Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. In Journal of Clinical Nutrition and Gastroenterology (3 ed., Vol. 6, pp. 137-142)

Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. / Braga, M.; Dal Cin, S.; Zerbi, A.; Cristallo, M.; Di Carlo, V.

Journal of Clinical Nutrition and Gastroenterology. Vol. 6 3. ed. 1991. p. 137-142.

Research output: Chapter in Book/Report/Conference proceedingChapter

Braga, M, Dal Cin, S, Zerbi, A, Cristallo, M & Di Carlo, V 1991, Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. in Journal of Clinical Nutrition and Gastroenterology. 3 edn, vol. 6, pp. 137-142.
Braga M, Dal Cin S, Zerbi A, Cristallo M, Di Carlo V. Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. In Journal of Clinical Nutrition and Gastroenterology. 3 ed. Vol. 6. 1991. p. 137-142
Braga, M. ; Dal Cin, S. ; Zerbi, A. ; Cristallo, M. ; Di Carlo, V. / Nutritional sequelae of post-surgical total exocrine pancreatic insufficiency. Journal of Clinical Nutrition and Gastroenterology. Vol. 6 3. ed. 1991. pp. 137-142
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