Nutritional status independently affects quality of life of patients with systemic immunoglobulin light-chain (AL) amyloidosis

Riccardo Caccialanza, Giovanni Palladini, Catherine Klersy, Emanuele Cereda, Chiara Bonardi, Barbara Cameletti, Elisabetta Montagna, Paola Russo, Andrea Foli, Paolo Milani, Francesca Lavatelli, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review

Abstract

Nutritional status is an independent prognostic factor in immunoglobulin light-chain amyloidosis (AL), but its influence on quality of life (QoL) is unknown. The aim of this cross-sectional study was to investigate the association between nutritional status and QoL in AL patients at diagnosis. One hundred and fifty consecutive patients with biopsy-proven AL were assessed for nutritional status by anthropometry [body mass index, unintentional weight loss (WL) in the previous 6 months and mid-arm muscle circumference (MAMC)], biochemistry (serum prealbumin), and semiquantitative food intake at referral. QoL was assessed by the Medical Outcomes Study 36-item Short Form General Health Survey. The composite physical component summary (PCS) and the mental component summary (MCS) for AL outpatients were 36.2 ± 10.1 and 44.9 ± 11.3, respectively (p <0.001 for both vs the population norms of 50). In multivariate linear regression models adjusted for gender, age, Eastern Cooperative Oncology Group performance status, the number of organs involved, the severity of cardiac damage, C-reactive protein, energy intake, and WL, PCS was significantly lower for serum prealbumin

Original languageEnglish
Pages (from-to)399-406
Number of pages8
JournalAnnals of Hematology
Volume91
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Amyloidosis
  • Malnutrition
  • Nutritional status
  • Prealbumin
  • Quality of life

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Nutritional status independently affects quality of life of patients with systemic immunoglobulin light-chain (AL) amyloidosis'. Together they form a unique fingerprint.

Cite this