Nutritional status of outpatients with systemic immunoglobulin light-chain amyloidosis

Riccardo Caccialanza, Giovanni Palladini, Catherine Klersy, Hellas Cena, Christina Vagia, Barbara Cameletti, Paola Russo, Francesca Lavatelli, Giampaolo Merlini

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Background: Maintenance of a good nutritional status is associated with prolonged survival in many chronic diseases. To date, the nutritional status of outpatients with immunoglobulin light-chain (AL) amyloidosis has not been evaluated. Objective: The aims of this study were to obtain information regarding the nutritional status of AL amyloidosis outpatients and to investigate its prognostic role. Design: One hundred six consecutive patients with histologically confirmed AL amyloidosis were enrolled. Anthropometric, biochemical, and clinical variables were measured. The Kaplan-Meier method was used to calculate survival. A Cox proportional hazard model was constructed to evaluate the prognostic effect of the nutritional variables. Results: Unintentional weight loss (median: 11.3%; range: 2.6-34% of usual nonedematous body weight) was documented in 58 subjects (54.7%). Body mass index (BMI; in kg/m2) was

Original languageEnglish
Pages (from-to)350-354
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Issue number2
Publication statusPublished - Feb 1 2006


  • Amyloidosis
  • Nutritional status
  • Outpatients
  • Prognosis
  • Survival
  • Weight loss

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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