Nutritional vitamin D in CKD: Should we measure? Should we treat?

Irene Capelli, Giuseppe Cianciolo, Lorenzo Gasperoni, Andrea Galassi, Paola Ciceri, Mario Cozzolino

Research output: Contribution to journalArticlepeer-review


Vitamin D deficiency is frequently present in patients affected by chronic kidney disease (CKD). Experimental studies demonstrated that Vitamin D may play a role in the pathophysiology of diseases beyond mineral bone disorders in CKD (CKD-MBD). Unfortunately, the lack of large and interventional studies focused on the so called “non-classic” effects of 25(OH) Vitamin D supplementation in CKD patients, doesn't permit to conclude definitely about the beneficial effects of this supplementation in clinical practice. In conclusion, treatment of nutritional vitamin D deficiency in CKD may play a central role in both bone homeostasis and cardiovascular outcomes, but there is not clear evidence to support one formulation of nutritional vitamin D over another in CKD.

Original languageEnglish
Pages (from-to)186-197
JournalClinica Chimica Acta
Publication statusPublished - 2020


  • Chronic kidney disease
  • Secondary hyperparathyroidism
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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