O-054. Lymphocyte subset pattern (LSP) in acromegaly

A. Colao, D. Ferone, A. Balzano, N. Panza, G. Grande, P. Marzullo, G. Cerbone, A. Di Sarno, B. Merola, G. Lombardi

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Neoplasms have been reported to occur (with a greater than expected incidence in acromegaly, but a few data have been provided on immune function. The aim of this study was to evaluate the prevalence malignancies in 50 acromegalics analyzing the LSP in peripheral blood and colonic lamina propria. One hundred Caucasian healthy subjects seeded as control. Fifty-two neoplastic lesions were found in 30 patients: 23 had colonic polyps, four adenomas (two thyroid, one parotid, one prostate), three lypomas, two bladder carcinomas, one brain astrocytoma, one basal-cell epithelioma. Coexistent neoplasms were found in six patients. Colonic polyps were found in 14 controls. A significant decrease of CD3, CD4 and increase of CD8, and CD19 was found in the periphery whereas in the colonic lamina propria CD3 was significantly increased and CD19 decreased These data suggest that (1) acromegalics have a higher prevalence of neoplastic lesions than controls and (2) chronic increase of GH/IGF-I might affect immune system presumably suppressing cellular mediated immunity and exalting humoral immune activity.

Original languageEnglish
Pages (from-to)30
Number of pages1
JournalEndocrinology and Metabolism, Supplement
Issue numberA
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Endocrinology


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