O-acylated sialic acid variants in mucinous tumours of the ovary

G. Lapertosa, P. Baracchini, E. Fulcheri, R. Tanzi

Research output: Contribution to journalArticlepeer-review


O-acylated sialic acid variants (site 8) can be demonstrated histochemically by the PB/KOH/PAS method. They are secreted by goblet cells of the lower gastrointestinal tract, by colorectal adenocarcinomas, and by their metastases. Since the metastases are positive only when the primary tumour is positive, O-acylated sialomucins can be considered to be specific markers of colorectal adenocarcinomas if identified in metastases of a tumour of unknown origin. In our histochemical study we evaluated 29 mucinous cystomas of the ovary (23 benign and 6 malignant). We found that six cases were positive to PB/KOH/PAS. The positivity was observed in a limited number of cells and only in areas which presented an intestinal type epithelium. It was also more evident in malignant cystomas than in benign ones. We therefore think that the PB/KOH/PAS positivity can not only be considered a marker of colorectal adenocarcinomas, but also of all neoplasms which originate from an intestinal epithelium or appear to an "intestinal type epithelium".

Original languageEnglish
Pages (from-to)395-402
Number of pages8
JournalVirchows Archiv A Pathological Anatomy and Histopathology
Issue number4
Publication statusPublished - Jul 1986


  • Histochemistry
  • Mucinous tumours
  • Mucins
  • O-acylated sialic acids
  • Ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Anatomy


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