O6-Alkylguanine-DNA alkyltransferase activity in human brain tumors

G. Frosina, O. Rossi, G. Arena, S. L. Gentile, E. Bruzzone, A. Abbondandolo

Research output: Contribution to journalArticle

Abstract

The O6-alkylguanine-DNA alkyltransferase (AT) activity in different kinds of human brain tumors was investigated. Twenty-seven brain tumors were analysed. Twenty-five of them showed proficient AT activity with values ranging between 20 and 722 fmol AT/mg protein. The two AT-deficient tumors observed were an oligodendroglioma and an astrocytoma. The relationship between the different histological kinds of tumor, with respect to the AT activity was: meningeomas > sarcomas > glioblastomas > astrocytomas > oligodendrogliomas > neurinomas > lymphomas. The proposal of Kohn (DNA filter elution methods in anticancer drug development. In: Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy. Editor: F.M. Muggia. Martinus Nijhoff Publishers, Boston) to confine treatments with alkylating antineoplastic agents to AT-deficient tumors, is discussed.

Original languageEnglish
Pages (from-to)153-158
Number of pages6
JournalCancer Letters
Volume55
Issue number2
DOIs
Publication statusPublished - Dec 3 1990

Keywords

  • brain tumors
  • chloroethylnitrosoureas
  • DNA repair
  • drug resistance
  • O-alkylguanine-DNA alkyltransferase

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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    Frosina, G., Rossi, O., Arena, G., Gentile, S. L., Bruzzone, E., & Abbondandolo, A. (1990). O6-Alkylguanine-DNA alkyltransferase activity in human brain tumors. Cancer Letters, 55(2), 153-158. https://doi.org/10.1016/0304-3835(90)90026-T