O6-Alkylguanine DNA alkyltransferase is induced by human recombinant interferon-αA/D in mouse liver

P. Coccia, R. Bertini, P. Pagani, C. Marinello, P. Taverna, P. Villa, M. D'Incalci

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of C57Bl or BALB/C mice with human interferon-αA/D (HuIFN- αA/D) significantly increased hepatic levels of the DNA repair enzyme O6- alkylguanine DNA alkyltransferase (AT). The maximum induction was seen 24 h after a single dose of 50-100 μg/kg IFN-αA/D. No induction was observed in rat liver hepatocytes cultured in vitro. Liver AT was also induced by poly(I : C), which is a potent IFN inducer. By increasing AT levels, IFN could protect against the potentially mutagenic alkylation at guanine O6 position caused by some carcinogens. Moreover this finding suggests a link between immune response and the DNA repair system, possibly acting in concert to defend the body from potentially toxic compounds.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalJournal of Interferon Research
Volume12
Issue number3
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Immunology
  • Virology

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