Abstract
Using L1210 and a subline resistance to chloroethylnitrosoureas (L1210/BCNU), we found that the resistance to 1-(2-chloroethyl)-1-nitrosourea (CNU) or to diethyl-1-3-(2-chloroethyl)-3-nitrosoureido ethyl phosphonate (fotemustine) can be reversed by a pretreatment with O6-methyl Guanine (O6-mGua) or temozolomide. In L1210/BCNU but not in L1210 the pretreatment with O6mGua caused an increased peak level of CNU-induced DNA-interstrand crosslinks. We then evaluated whether the resistance to BCNU could be counteracted in vivo by i.p. O6mGua treatment of L1210/BCNU bearing mice. The results were negative due to the fact that O6mGua, which was not toxic when given alone, caused a high toxicity when associated with BCNU.
| Original language | English |
|---|---|
| Pages (from-to) | 115-121 |
| Number of pages | 7 |
| Journal | Anticancer Research |
| Volume | 11 |
| Issue number | 1 |
| Publication status | Published - 1991 |
Keywords
- nitrosoureas
- O-alkylguanine DNA alkyl transferase
- O-methylguanine
ASJC Scopus subject areas
- Cancer Research
- Oncology
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D'Incalci, M., Taverna, P., Erba, E., Filippeschi, S., Potenza, D., Mariani, L., Citti, L., & Catapano, C. V. (1991). O6-methylguanine and temozolomide can reverse the resistance to chloroethylnitrosoureas of a mouse L1210 leukemia. Anticancer Research, 11(1), 115-121.