OA frequency at long-term follow-up is a concern in patients with cartilage repair. Perspective

Giuseppe Filardo

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•No currently available treatment may provide optimal results either in terms of cartilage regeneration or clinical improvement. However, there is an increasing awareness that the quality of the repaired/regenerated tissue plays a key role in determining the final outcome, especially the long-term results. Several treatments are emerging aimed at restoring a hyaline articular surface. At the same time, the literature shows how not all patients may benefit equally from the different cartilage treatment options, with lower results and a higher failure rate in more degenerated joints where the regenerative potential may be not sufficient to offer good results after a regenerative treatment. Thus, results of some studies may be affected by the patient selection. One such study is this long-term autologous chondrocyte implantation vs. microfracture (MFX) study which shows a high percentage of osteoarthritis occurred since the first follow-up, which means possibly a population was targeted after the point of no return in the degenerative progression and, therefore, they were not the best candidates for a regenerative procedure. On the other hand, as documented in the experience of our group and by an increasing number of literature reports, non-degenerative lesions can benefit more from a regenerative approach, which in this patient population may offer longer-lasting results than MFX.
Original languageEnglish
JournalOrthopaedic Today Europe
Publication statusPublished - 2015


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