OA frequency at long-term follow-up is a concern in patients with cartilage repair. Perspective

Research output: Contribution to journalArticle

Abstract

•No currently available treatment may provide optimal results either in terms of cartilage regeneration or clinical improvement. However, there is an increasing awareness that the quality of the repaired/regenerated tissue plays a key role in determining the final outcome, especially the long-term results. Several treatments are emerging aimed at restoring a hyaline articular surface. At the same time, the literature shows how not all patients may benefit equally from the different cartilage treatment options, with lower results and a higher failure rate in more degenerated joints where the regenerative potential may be not sufficient to offer good results after a regenerative treatment. Thus, results of some studies may be affected by the patient selection. One such study is this long-term autologous chondrocyte implantation vs. microfracture (MFX) study which shows a high percentage of osteoarthritis occurred since the first follow-up, which means possibly a population was targeted after the point of no return in the degenerative progression and, therefore, they were not the best candidates for a regenerative procedure. On the other hand, as documented in the experience of our group and by an increasing number of literature reports, non-degenerative lesions can benefit more from a regenerative approach, which in this patient population may offer longer-lasting results than MFX.
Original languageEnglish
JournalOrthopaedic Today Europe
Publication statusPublished - 2015

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