Oats in the diet of children with celiac disease: Preliminary results of a double-blind, randomized, placebo-controlled multicenter Italian study

Simona Gatti, Nicole Caporelli, Tiziana Galeazzi, Ruggiero Francavilla, Maria Barbato, Paola Roggero, Basilio Malamisura, Giuseppe Iacono, Andrea Budelli, Rosaria Gesuita, Carlo Catassi, Elena Lionetti

Research output: Contribution to journalArticle

Abstract

A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet "A", 3 months of standard GFD, 6 months of diet "B"), or B-A treatment (6 months of diet "B", 3 months of standard GFD, 6 months of diet "A"). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.

Original languageEnglish
Pages (from-to)4653-4664
Number of pages12
JournalNutrients
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 20 2013

Keywords

  • Celiac disease
  • Gastrointestinal symptoms
  • Gluten-free diet
  • Intestinal permeability
  • Oats

ASJC Scopus subject areas

  • Food Science

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    Gatti, S., Caporelli, N., Galeazzi, T., Francavilla, R., Barbato, M., Roggero, P., Malamisura, B., Iacono, G., Budelli, A., Gesuita, R., Catassi, C., & Lionetti, E. (2013). Oats in the diet of children with celiac disease: Preliminary results of a double-blind, randomized, placebo-controlled multicenter Italian study. Nutrients, 5(11), 4653-4664. https://doi.org/10.3390/nu5114653