Ob-Stopping obesity, metabolic and immune-mediated disorders

Giuseppe Matarese, Veronica De Rosa

Research output: Contribution to journalArticlepeer-review


Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb).

Original languageEnglish
Pages (from-to)385-387
Number of pages3
Issue number3
Publication statusPublished - Mar 7 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology


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