Obesità e rischio cardiovascolare in età pediatrica. Spunti di riflessione dallo studio ORIGIN

Translated title of the contribution: Obesity and cardiovascular risk in children

Blegina Shashaj, Maria Pia Graziani, Alberto Eugenio Tozzi, Melania Manco

Research output: Contribution to journalArticlepeer-review


Prevalence of overweight and obesity in childhood has substantially increased worldwide in recent decades with children becoming obese at progressively younger ages. Obesity in children carries a wide range of serious complications, and contributes to an increased prevalence of cardiovascular risk factors such as hypertension, hypertrygliceridema, low high-density lipoprotein cholesterol (HDL), impaired glucose metabolism and early atherosclerotic changes not only in adulthood but since in very early pediatric age. In the ORIGIN study (Outcome Reduction with an Initial Glargine Intervention), cardiometabolic risk factors including fatty liver were already detectable in preschoolers at the onset of overweight/obesity despite short-term exposure to excess weight and fairly reduced insulin sensitivity. These facts together with the evidence that early cardiometabolic impairment reverts with lifestyle intervention in pediatric age, emphasize the need to start prevention of childhood obesity and screening of cardiometabolic co-morbities at the earliest stage with multidisciplinary strategies.

Translated title of the contributionObesity and cardiovascular risk in children
Original languageItalian
Pages (from-to)454-456
Number of pages3
JournalRecenti Progressi in Medicina
Issue number12
Publication statusPublished - Dec 1 2014

ASJC Scopus subject areas

  • Medicine(all)


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