Obesity and glucose metabolism

Nicola Napoli; Paolo Pozzilli

doi:10.1007/978-3-319-09045-0_11

Obesity and glucose metabolism

Nicola Napoli, Paolo Pozzilli

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.

Original language	English
Title of host publication	Multidisciplinary Approach to Obesity: From Assessment to Treatment
Publisher	Springer International Publishing
Pages	107-119
Number of pages	13
ISBN (Print)	9783319090450, 9783319090443
DOIs	https://doi.org/10.1007/978-3-319-09045-0_11
Publication status	Published - Jan 1 2015

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-09045-0_11

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AB - Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.

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Obesity and glucose metabolism

Abstract

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