Abstract
Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.
| Original language | English |
|---|---|
| Title of host publication | Multidisciplinary Approach to Obesity: From Assessment to Treatment |
| Publisher | Springer International Publishing |
| Pages | 107-119 |
| Number of pages | 13 |
| ISBN (Print) | 9783319090450, 9783319090443 |
| DOIs | |
| Publication status | Published - Jan 1 2015 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Obesity and glucose metabolism. / Napoli, Nicola; Pozzilli, Paolo.
Multidisciplinary Approach to Obesity: From Assessment to Treatment. Springer International Publishing, 2015. p. 107-119.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Obesity and glucose metabolism
AU - Napoli, Nicola
AU - Pozzilli, Paolo
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.
AB - Obesity is associated with multiple metabolic alterations that are risk factors for glucose homeostasis abnormalities, cardiovascular diseases, and nonalcoholic fatty liver disease. It is believed that insulin resistance in the adipose tissue, liver, and skeletal muscle is crucial in the pathogenesis of these metabolic abnormalities. Adipocytes are key regulators of whole-body energy homeostasis, and altered adipose tissue glucose metabolism is also an important cause of insulin resistance and metabolic function. Adipose tissue contributes to the development of obesity-related glucose abnormalities through excessive release of free fatty acids (FFA), adipokines, cytokines, and macrophage infiltration.
UR - http://www.scopus.com/inward/record.url?scp=84943805191&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943805191&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-09045-0_11
DO - 10.1007/978-3-319-09045-0_11
M3 - Chapter
AN - SCOPUS:84943805191
SN - 9783319090450
SN - 9783319090443
SP - 107
EP - 119
BT - Multidisciplinary Approach to Obesity: From Assessment to Treatment
PB - Springer International Publishing
ER -