Obesità ed ipertensione: Ruolo del magnesio

Translated title of the contribution: Obesity and hypertension: The role of magnesium

Francesco Corica, Alessandro Allegra, Michele Buemi, Riccardo Ientile, Andrea Corsonello, Salvatore Bonanzinga, Salvatore Macaione, Domenico Ceruso

Research output: Contribution to journalArticlepeer-review

Abstract

We focus on the recent "ionic hypothesis", in which an alteration of ionic metabolism represents a peculiar event in the pathogenesis of obesity and hypertension. We report the results from our original studies in which we evaluated intraplatelet magnesium levels. In a study on normotensive and hypertensive patients with non insulin-dependent diabetes mellitus and healthy control subjects, we showed a common reduction of plasma, erythrocyte and platelet magnesium levels in both normotensive and hypertensive diabetics with respect to control. Anyway, hypertensive diabetics showed a greater reduction of intraplatelet magnesium concentrations when compared to normotensive diabetics. Using the same technique, we found reduced erythrocyte and platelet magnesium concentrations in patients with essential hypertension with respect to the control group. In a successive study, we found, in the group of normotensive obeses, that erythrocyte and platelet magnesium levels were significantly lower than those of the control group, while in hypertensive obese patients a reduction of plasma magnesium levels has been also detected. In conclusion, in these studies has been confirmed the existence of a reduction of the intracellular magnesium concentrations, which is common in hypertensive and obese patients.

Translated title of the contributionObesity and hypertension: The role of magnesium
Original languageItalian
Pages (from-to)169-176
Number of pages8
JournalRecenti Progressi in Medicina
Volume89
Issue number4
Publication statusPublished - Apr 1998

ASJC Scopus subject areas

  • Medicine(all)

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