Abstract
This study investigates motor (MNCS) and sensory (SNCS) nerve conduction in a sample of non-diabetic obese people without symptoms suggestive of neuropathy and looks for a possible metabolic alteration. Twenty-one patients and 20 age-matched controls underwent (a) MNCS (median, ulnar, peroneal, and tibial) and SNCS (median, ulnar, and sural); (b) quantitative sensory testing to measure sensory threshold for vibration, warm and cold sensation (WS-CS), heat and cold-induced pain; and (c) blood sample analysis to evaluate glucose and insulin levels and calculate the quantitative insulin-sensitivity check index (QUICKI). The obese group showed significantly decreased compound muscle action potential amplitude of tibial and peroneal nerves and decreased sensory action potential amplitude of all nerves. Most of the sensory thresholds were altered in obese patients. Insulin serum levels were significantly increased while QUICKI decreased in obese patients. WS and CS from the index and little fingers and WS from the big toe significantly correlated with QUICKI. Thermal and pain thresholds from the index and thermal thresholds from the little finger correlated with QUICKI values. The non-diabetic obese patients showed a subclinical involvement of different diameter sensory fibers. Such impairment was related to hyperinsulinemia and insulin sensitivity. The increase in sensory threshold of obese patients might be due to a metabolic alteration, potentially leading to a future clinical neuropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 354-358 |
| Number of pages | 5 |
| Journal | Journal of the Peripheral Nervous System |
| Volume | 10 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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Keywords
- Diabetes
- Insulin resistance
- Neuropathy
- Obesity
- Sensory thresholds
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Obesity and peripheral neuropathy risk : A dangerous liaison. / Miscio, Giacinta; Guastamacchia, Giulia; Brunani, Amelia; Priano, Lorenzo; Baudo, Silvia; Mauro, Alessandro.
In: Journal of the Peripheral Nervous System, Vol. 10, No. 4, 12.2005, p. 354-358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obesity and peripheral neuropathy risk
T2 - A dangerous liaison
AU - Miscio, Giacinta
AU - Guastamacchia, Giulia
AU - Brunani, Amelia
AU - Priano, Lorenzo
AU - Baudo, Silvia
AU - Mauro, Alessandro
PY - 2005/12
Y1 - 2005/12
N2 - This study investigates motor (MNCS) and sensory (SNCS) nerve conduction in a sample of non-diabetic obese people without symptoms suggestive of neuropathy and looks for a possible metabolic alteration. Twenty-one patients and 20 age-matched controls underwent (a) MNCS (median, ulnar, peroneal, and tibial) and SNCS (median, ulnar, and sural); (b) quantitative sensory testing to measure sensory threshold for vibration, warm and cold sensation (WS-CS), heat and cold-induced pain; and (c) blood sample analysis to evaluate glucose and insulin levels and calculate the quantitative insulin-sensitivity check index (QUICKI). The obese group showed significantly decreased compound muscle action potential amplitude of tibial and peroneal nerves and decreased sensory action potential amplitude of all nerves. Most of the sensory thresholds were altered in obese patients. Insulin serum levels were significantly increased while QUICKI decreased in obese patients. WS and CS from the index and little fingers and WS from the big toe significantly correlated with QUICKI. Thermal and pain thresholds from the index and thermal thresholds from the little finger correlated with QUICKI values. The non-diabetic obese patients showed a subclinical involvement of different diameter sensory fibers. Such impairment was related to hyperinsulinemia and insulin sensitivity. The increase in sensory threshold of obese patients might be due to a metabolic alteration, potentially leading to a future clinical neuropathy.
AB - This study investigates motor (MNCS) and sensory (SNCS) nerve conduction in a sample of non-diabetic obese people without symptoms suggestive of neuropathy and looks for a possible metabolic alteration. Twenty-one patients and 20 age-matched controls underwent (a) MNCS (median, ulnar, peroneal, and tibial) and SNCS (median, ulnar, and sural); (b) quantitative sensory testing to measure sensory threshold for vibration, warm and cold sensation (WS-CS), heat and cold-induced pain; and (c) blood sample analysis to evaluate glucose and insulin levels and calculate the quantitative insulin-sensitivity check index (QUICKI). The obese group showed significantly decreased compound muscle action potential amplitude of tibial and peroneal nerves and decreased sensory action potential amplitude of all nerves. Most of the sensory thresholds were altered in obese patients. Insulin serum levels were significantly increased while QUICKI decreased in obese patients. WS and CS from the index and little fingers and WS from the big toe significantly correlated with QUICKI. Thermal and pain thresholds from the index and thermal thresholds from the little finger correlated with QUICKI values. The non-diabetic obese patients showed a subclinical involvement of different diameter sensory fibers. Such impairment was related to hyperinsulinemia and insulin sensitivity. The increase in sensory threshold of obese patients might be due to a metabolic alteration, potentially leading to a future clinical neuropathy.
KW - Diabetes
KW - Insulin resistance
KW - Neuropathy
KW - Obesity
KW - Sensory thresholds
UR - http://www.scopus.com/inward/record.url?scp=33644839983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644839983&partnerID=8YFLogxK
U2 - 10.1111/j.1085-9489.2005.00047.x
DO - 10.1111/j.1085-9489.2005.00047.x
M3 - Article
C2 - 16279984
AN - SCOPUS:33644839983
VL - 10
SP - 354
EP - 358
JO - Journal of the Peripheral Nervous System
JF - Journal of the Peripheral Nervous System
SN - 1085-9489
IS - 4
ER -