Obesity, nonalcoholic fatty liver disease and adipocytokines network in promotion of cancer

Rosa Divella, Antonio Mazzocca, Antonella Daniele, Carlo Sabbà, Angelo Paradiso

Research output: Contribution to journalReview articlepeer-review

Abstract

Western populations are becoming increasingly sedentary and the incidence of nonalcoholic fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of liver disease worldwide. Also, NAFLD is considered one the new emerging risk factors for development of tumors of the gastro-intestinal tract, particularly hepatocellular carcinoma (HCC). Visceral obesity is an important risk factor for the onset of NAFLD. An accumulation of ectopic fat, including visceral obesity and fatty liver leads to a dysfunction of the adipose tissue with impaired production of adipocytokines which, in turn, favor an increase in pro-inflammatory cytokines. In this review, we discuss how the obesity-related chronic state of low-grade inflammation and the presence of NAFLD lead to the emergence of a microenvironment favorable to the development of cancer.

Original languageEnglish
Pages (from-to)610-616
Number of pages7
JournalInternational Journal of Biological Sciences
Volume15
Issue number3
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Adipocytokines
  • Cancer
  • Inflammation
  • NAFLD
  • Obesity

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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