Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose of review: There is emerging evidence that obesity is associated with an increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. Here, we discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, we discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of breast reconstruction and the related risks. Recent findings: In several murine models, WAT cells and progenitors were found to have cooperative roles in promoting local breast cancer. Moreover, they were found to contribute to adipocytes and pericytes supporting the cancer vasculature, and stimulated the metastatic progression of breast cancer. There are some clinically retrospective data showing a significant increase in the frequency of intraepithelial neoplasia in patients who received a lipofilling procedure for breast reconstruction compared with controls. Summary: Preclinical models and clinical studies are urgently needed to investigate how to inhibit the tumor-promoting activity of WAT cells and progenitors. The risks associated with the use of WAT cells for breast reconstructions should be better investigated retrospectively and prospectively.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalCurrent Opinion in Oncology
Volume26
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

White Adipose Tissue
Adipose Tissue
Obesity
Mammaplasty
Breast Neoplasms
Stem Cells
Neoplasms
Pericytes
Adipocytes
Mortality
Incidence
Growth

Keywords

  • Adipose tissue progenitors
  • Breast cancer
  • Obesity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer. / Bertolini, Francesco; Orecchioni, Stefania; Petit, Jean Yves; Kolonin, Mikhail G.

In: Current Opinion in Oncology, Vol. 26, No. 6, 2014, p. 545-550.

Research output: Contribution to journalArticle

@article{3bc17103b1244fe7b9f8cdf69bbf57c9,
title = "Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer",
abstract = "Purpose of review: There is emerging evidence that obesity is associated with an increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. Here, we discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, we discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of breast reconstruction and the related risks. Recent findings: In several murine models, WAT cells and progenitors were found to have cooperative roles in promoting local breast cancer. Moreover, they were found to contribute to adipocytes and pericytes supporting the cancer vasculature, and stimulated the metastatic progression of breast cancer. There are some clinically retrospective data showing a significant increase in the frequency of intraepithelial neoplasia in patients who received a lipofilling procedure for breast reconstruction compared with controls. Summary: Preclinical models and clinical studies are urgently needed to investigate how to inhibit the tumor-promoting activity of WAT cells and progenitors. The risks associated with the use of WAT cells for breast reconstructions should be better investigated retrospectively and prospectively.",
keywords = "Adipose tissue progenitors, Breast cancer, Obesity",
author = "Francesco Bertolini and Stefania Orecchioni and Petit, {Jean Yves} and Kolonin, {Mikhail G.}",
year = "2014",
doi = "10.1097/CCO.0000000000000130",
language = "English",
volume = "26",
pages = "545--550",
journal = "Current Opinion in Oncology",
issn = "1040-8746",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer

AU - Bertolini, Francesco

AU - Orecchioni, Stefania

AU - Petit, Jean Yves

AU - Kolonin, Mikhail G.

PY - 2014

Y1 - 2014

N2 - Purpose of review: There is emerging evidence that obesity is associated with an increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. Here, we discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, we discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of breast reconstruction and the related risks. Recent findings: In several murine models, WAT cells and progenitors were found to have cooperative roles in promoting local breast cancer. Moreover, they were found to contribute to adipocytes and pericytes supporting the cancer vasculature, and stimulated the metastatic progression of breast cancer. There are some clinically retrospective data showing a significant increase in the frequency of intraepithelial neoplasia in patients who received a lipofilling procedure for breast reconstruction compared with controls. Summary: Preclinical models and clinical studies are urgently needed to investigate how to inhibit the tumor-promoting activity of WAT cells and progenitors. The risks associated with the use of WAT cells for breast reconstructions should be better investigated retrospectively and prospectively.

AB - Purpose of review: There is emerging evidence that obesity is associated with an increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. Here, we discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, we discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of breast reconstruction and the related risks. Recent findings: In several murine models, WAT cells and progenitors were found to have cooperative roles in promoting local breast cancer. Moreover, they were found to contribute to adipocytes and pericytes supporting the cancer vasculature, and stimulated the metastatic progression of breast cancer. There are some clinically retrospective data showing a significant increase in the frequency of intraepithelial neoplasia in patients who received a lipofilling procedure for breast reconstruction compared with controls. Summary: Preclinical models and clinical studies are urgently needed to investigate how to inhibit the tumor-promoting activity of WAT cells and progenitors. The risks associated with the use of WAT cells for breast reconstructions should be better investigated retrospectively and prospectively.

KW - Adipose tissue progenitors

KW - Breast cancer

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84927639286&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927639286&partnerID=8YFLogxK

U2 - 10.1097/CCO.0000000000000130

DO - 10.1097/CCO.0000000000000130

M3 - Article

C2 - 25279961

AN - SCOPUS:84927639286

VL - 26

SP - 545

EP - 550

JO - Current Opinion in Oncology

JF - Current Opinion in Oncology

SN - 1040-8746

IS - 6

ER -