Obesity, type 2 diabetes mellitus and cardiovascular disease risk: An uptodate in the management of polycystic ovary syndrome

Francesco Orio, Giovanna Muscogiuri, Cinar Nese, Stefano Palomba, Silvia Savastano, Domenico Tafuri, Giorgio Colarieti, Giovanbattista La Sala, Annamaria Colao, Bulent O. Yildiz

Research output: Contribution to journalArticlepeer-review


Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive aged women and is characterized by two of the following three features: oligoovulation or anovulation, clinical and/or biochemical signs of hyperandrogenism, or polycystic ovaries. Summary: It has been demonstrated that PCOS includes a complex number of systemic symptoms in addition to symptoms related to the reproductive apparatus. It has been associated with obesity, metabolic syndrome, type 2 diabetes and an increased risk of cardiovascular disease. Several clinical and basic studies have investigated the link between PCOS and the cardiovascular disease risk, which seems to be due to blunted lipid/glucose metabolism, hypertension, and systemic inflammatory and coagulation disorders. Therefore, the current manuscript aims to review the main findings on PCOS and obesity/. obesity-related disease (glucose derangements and cardiovascular disease risk factors). Key message: Although there are no long-term data on the morbidity and mortality for cardiovascular disease in PCOS, it is advisable to perform a careful metabolic and cardiovascular assessment in women with PCOS in order to tailor the most suitable strategy to prevent cardiovascular disease.

Original languageEnglish
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Publication statusAccepted/In press - Jun 22 2016


  • Cardiovascular disease
  • Environment
  • Lifestyle
  • Obesity
  • PCOS
  • Type 2 diabetes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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