Observational multicenter study on the prognostic relevance of coagulation activation in risk assessment and stratification in locally advanced breast cancer. Outline of the arias trial

Laura Pizzuti, Eriseld Krasniqi, Chiara Mandoj, Daniele Marinelli, Domenico Sergi, Elisabetta Capomolla, Giancarlo Paoletti, Claudio Botti, Ramy Kayal, Francesca Romana Ferranti, Isabella Sperduti, Letizia Perracchio, Giuseppe Sanguineti, Paolo Marchetti, Gennaro Ciliberto, Giacomo Barchiesi, Marco Mazzotta, Maddalena Barba, Laura Conti, Patrizia Vici

Research output: Contribution to journalArticlepeer-review

Abstract

A hypercoagulable state may either underlie or frankly accompany cancer disease at its onset or emerge in course of cancer development. Whichever the case, hypercoagulation may severely limit administration of cancer therapies, impose integrative supporting treatments and finally have an impact on prognosis. Within a flourishing research pipeline, a recent study of stage I-IIA breast cancer patients has allowed the development of a prognostic model including biomarkers of coagulation activation, which efficiently stratified prognosis of patients in the study cohort. We are now validating our risk assessment tool in an independent cohort of 108 patients with locally advanced breast cancer with indication to neo-adjuvant therapy followed by breast surgery. Within this study population, we will use our tool for risk assessment and stratification in reference to 1. pathologic complete response rate at definitive surgery, intended as our primary endpoint, and 2. rate of thromboembolic events, intended as our secondary endpoint. Patients’ screening and enrollment procedures are currently in place. The trial will be shortly enriched by experimental tasks centered on next-generation sequencing techniques for identifying additional molecular targets of treatments which may integrate current standards of therapy in high-risk patients.

Original languageEnglish
Article number849
Pages (from-to)1-8
Number of pages8
JournalCancers
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 2020

Keywords

  • Locally advanced breast cancer
  • PCR
  • Prognostic model
  • Venous thromboembolism
  • �coagulation activation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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