Observational multicentric study on chronic sciatic pain: clinical data from 44 Italian centers

G. A. Checchia, G. Letizia Mauro, G. Morico, A. Oriente, C. Lisi, V. Polimeni, M. Lucia, M. Ranieri, Management of Peripheral Neuropathies Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To provide information on the clinical presentation of sciatic neuropathy and its management in a real-world setting, and to analyze the effects of a multimodal approach based on the association of physical and pharmacological therapy. PATIENTS AND METHODS: A multicentric observational prospective study was conducted in 44 Italian tertiary centers specialized in Physical Medicine and Rehabilitation, Orthopedics, Neurology, Neurosurgery, and Rheumatology. To develop a shared management of LPB with sciatica, a dedicated clinical record was proposed to collect data about diagnosis, treatment, and outcomes. Pain, disability, and quality of life were recorded trough validated questionnaires at baseline and after a two-month follow-up. RESULTS: 394 patients (age, mean +/- SD 55.7 +/- 14.1 years, 57.1% females) with chronic LBP and sciatica were enrolled in the study. The characteristics of the selected group showed a certain variability in the clinical presentation. At baseline, patients received several different therapeutic options among physical, pharmacological and neurotrophic treatments. A subgroup of 312 patients was treated with a combination of neurotrophic agents containing alpha-lipoic acid (ALA). After a two-month follow-up, a general improvement in both perceived pain and functional disabilities was observed. A significant improvement (p <0.001) in the Pain Numeric Rating Scale (NRS), Roland e Morris Disability Questionnaire (RMDQ) and Brief Pain Inventory (BPI) Italian short version was observed. CONCLUSIONS: Sciatic neuropathy is a multifaceted condition managed by means of a wide spectrum of therapeutic options. The results of this study suggest that a multimodal approach based on the association of ALA with physical and pharmacological therapies can be beneficial in the treatment of LBP with sciatica.
Original languageEnglish
Pages (from-to)1653-1664
Number of pages12
JournalEuropean Review for Medical and Pharmacological Sciences
Volume21
Issue number7
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Adult
  • Chronic Pain
  • Disability Evaluation
  • Female
  • Humans
  • Italy
  • Low Back Pain/physiopathology/psychology/therapy
  • Middle Aged
  • Pain Measurement
  • Prospective Studies
  • Quality of Life
  • Sciatic Nerve
  • Surveys and Questionnaires
  • Treatment Outcome

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