OSSERVAZIONI SU 112 FEGATI PRELEVATI CON DIFFERENTI MODALITA DI PERFUSIONE E CONSERVAZIONE

Translated title of the contribution: Observations on 112 livers harvested by different methods of perfusion and preservation

L. Caccamo, M. Colledan, M. Doglia, L. Rainero Fassati, G. Ferla, S. Gatti, B. Gridelli, A. Lucianetti, U. Maggi, G. Paone, A. Piazzini Albani, P. Reggiani, G. Rossi, D. Galmarini

Research output: Contribution to journalArticle

Abstract

The safety and the efficacy of UW solution have been widely proved for extended preservation of the human liver, and today UW solution is the preferred fluid for liver preservation not only because of the longer preservation time but also because of the improved results. The aim of this retrospective study is to compare the results obtained with four different methods of hepatic preservation. In the first group (RLEC) 28 livers were harvested using in situ Ringer lactate solution and ex vivo Eurocollins solution; the latter was substituted with UW solution in the following 35 harvested livers included in the second group (RLUW); UW solution alone was used both in situ and ex vivo flushing in the 24 livers of the third group (UWUW); and the latter group (TCIP) includes 25 livers harvested as in the UWUW group, but transplanted in a semielective matter causing a prolonged ischemic preservation time. The results reflect the protective effects of the UW solution against the ischemic damage, as showed by the analysis of the peaks of transaminases in the first postoperative week that are lower when only this solution has been employed (UWUW and TCIE groups versus RLEC and RLUW groups) and as expressed by the better and more stable functional parameters (one month prothrombin activity RLEC versus UWUW p = 0,005, RLEC versus TCIE p = 0,0594). The incidence of primary non function has reduced with UW solution versus Eurocollins preservation and it was not related to the ischemic time (no primary non function occurred in the TCIE group), but to some structural abnormalities of the graft as severe steatosis and or swelling. We underline the importance of the histologic study of the harvested liver during the preservation time in order to avoid the implantation of pathological grafts.

Translated title of the contributionObservations on 112 livers harvested by different methods of perfusion and preservation
Original languageItalian
Pages (from-to)91-98
Number of pages8
JournalChirurgia
Volume6
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Surgery

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  • Cite this

    Caccamo, L., Colledan, M., Doglia, M., Rainero Fassati, L., Ferla, G., Gatti, S., Gridelli, B., Lucianetti, A., Maggi, U., Paone, G., Piazzini Albani, A., Reggiani, P., Rossi, G., & Galmarini, D. (1993). OSSERVAZIONI SU 112 FEGATI PRELEVATI CON DIFFERENTI MODALITA DI PERFUSIONE E CONSERVAZIONE. Chirurgia, 6(3), 91-98.