Observer reproducibility of results from a low-dose 123I- metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure

Teresa Pellegrino, Mario Petretta, Serena De Luca, Stefania Paolillo, Antonio Boemio, Raffaella Carotenuto, Maria Piera Petretta, Carmine Di Nuzzo, Pasquale Perrone-Filardi, Alberto Cuocolo

Research output: Contribution to journalArticle

Abstract

Purpose: Imaging of the cardiac autonomic system with 123I- metaiodobenzylguanidine (MIBG) is useful in the evaluation of patients with a variety of cardiac conditions, including heart failure (HF), but few data are available about the reproducibility of this technique. We assessed the observer reproducibility of the results from a low-dose 123I-MIBG cardiac imaging protocol in patients with HF. Methods: A total of 74 patients (62 men, age 67±10 years) with HF and left ventricular systolic dysfunction (ejection fraction 31±7 %) underwent low-dose (111 MBq) planar and single-photon emission computed tomography (SPECT) 123I-MIBG cardiac sympathetic imaging. The intraclass coefficient of correlation (ICC), Lin's concordance correlation coefficient, and Bland-Altman analysis were used to evaluate the intraobserver and interobserver reproducibility of early and late heart-to-mediastinum (H/M) ratios and of defect scores on SPECT images. The κ statistic was used to evaluate the concordance rates for the identification of patients with a low H/M ratio (0.90) for all measurements. For the identification of patients with a low H/M ratio, the κ values were 0.90 for intraobserver concordance and 0.83 for interobserver concordance. Conclusion: The present study showed a high observer reproducibility of planar H/M ratios and SPECT defect scores using a low-dose 123I-MIBG cardiac imaging protocol in patients with HF.

Original languageEnglish
Pages (from-to)1549-1557
Number of pages9
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number10
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Low-dose protocol
  • MIBG cardiac imaging
  • Planar
  • Reproducibility
  • Single-photon emission computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Pellegrino, T., Petretta, M., De Luca, S., Paolillo, S., Boemio, A., Carotenuto, R., Petretta, M. P., Di Nuzzo, C., Perrone-Filardi, P., & Cuocolo, A. (2013). Observer reproducibility of results from a low-dose 123I- metaiodobenzylguanidine cardiac imaging protocol in patients with heart failure. European Journal of Nuclear Medicine and Molecular Imaging, 40(10), 1549-1557. https://doi.org/10.1007/s00259-013-2461-4